摘要
芳香烃受体(AhR)是一种配体激活的转录因子,通过与其配体结合,启动下游靶基因转录,发挥相应的生物学效应。AhR可调控雌(女)性哺乳动物卵泡的生长、卵巢激素的合成、分泌及排卵;AhR信号通路与月经周期亦相关,可能通过调控雌激素信号系统改变子宫内膜的增殖和分泌。AhR在胎盘的表达水平最高,且主要分布于胎盘滋养层细胞和胎盘血管内皮细胞,其可能通过影响葡萄糖的转运和代谢系统影响胎盘功能。AhR基因敲除小鼠不能正常维持胚胎的植入和胎仔的发育,另外,即使胚胎着床后也不能维持正常妊娠和哺乳,且同胎出生仔数减少、出生后2周幼仔存活率低、断奶后死亡率高。
The aryl hydrocarbon receptor(AhR) is a ligand-dependent transcription factor.Upon binding to its ligands,AhR regulates expression of the AhR battery of target genes and mediates a variety of biological processes.AhR regulates the follicular growth,synthesization and secretion of ovarian hormones and ovulation.The signal pathway of AhR is also related with menstrual cycle and may change the proliferation and secretion of endometrium through regulating the signal system of estrogen.The expression of AhR in placenta is the highest,and mainly expresses in trophoblast cells and vascular endothelial cells,thus,AhR maybe affect placental fuction through influencing transport and metabolize of glucose.The mice which are knoched out AhR gene could not maintain implantation of embryos and development of fetus normally,in addition,normal pregnancy and lactation may not be maintained after implantation with decreased number of newborn mice,low alive rate of 2-week-old mice and high mortality after ablactation.
出处
《生殖与避孕》
CAS
CSCD
2012年第12期844-847,836,共4页
Reproduction and Contraception
基金
国家自然科学基金项目(编号:81100429)
上海市自然科学基金项目(编号:11ZR1428700)
关键词
芳香烃受体
生殖系统
胎盘
aryl hydrocarbon receptor
reproduction
placenta
