摘要
目的 建立 3种新型α1 受体拮抗剂阿夫唑嗪、特拉唑嗪、多沙唑嗪的手性分离方法。方法 通过探讨环糊精的种类、浓度、缓冲液的浓度、pH值对分离的影响 ,选择手性分离的最佳条件。结果 3种新型α1 受体阻断剂的光学异构体得到基线分离。
AIM To establish new methods for the chiral sepatation of three new drugs, ie, alfuzosin, terazosin and doxazosin. METHODS By optimizing factors which affect the chiral separation, the kinds and concentrations of cyclodextrin, the pH value and the concentration of buffer, the optimum conditions for chiral separation were selected. RESULTS The enantiomers of three new drugs were base line separated. CONCLUSION The newly established method can be used to study the enantiomers of three new drugs.
出处
《药学学报》
CAS
CSCD
北大核心
2000年第6期451-453,共3页
Acta Pharmaceutica Sinica
关键词
高效毛细管电泳法
手性分离
α1-受体阻断剂
high performance capillary electrophoresis
chiral separation
alfuzosin
terazosin
doxazosin
