摘要
目的分析医院腹腔感染患者细菌分布及其耐药性,指导临床合理应用抗菌药物及感染管理。方法回顾性分析2006-2010年来医院就诊患者腹腔标本分离病原菌的分布及耐药性。结果共分离出细菌158株,其中革兰阳性球菌74株占46.84%,革兰阴性杆菌84株占53.16%;排前6位的病原菌为大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌、屎肠球菌、肺炎克雷伯菌、表皮葡萄球菌分别为16.45%、15.19%、10.76%、9.49%、8.86%、8.86%;产超广谱β-内酰胺酶大肠埃希菌、肺炎克雷伯菌检出率为65.38%和42.86%;屎肠球菌对万古霉素、利奈唑胺的耐药率均为6.67%;耐甲氧西林金黄色葡萄球菌、凝固酶阴性葡萄球菌的检出率分别为80.0%与74.3%,未检测出耐万古霉素、利奈唑胺菌株;铜绿假单胞菌的多药耐药率高达44.1%,对头孢哌酮/舒巴坦的耐药率仅17.65%。结论医院腹腔感染中革兰阴性菌与革兰阳性菌比例相当,多药耐药性比例高;依据细菌及耐药性监测结果指导抗菌药物的合理应用,是治疗腹腔感染的重要手段。
OBJECTIVE To investigate the distribution and drug resistance of bacteria isolated from patients withintra-abdominal infections so as to guide the reasonable application of antibiotics and the control of infections. METHODS Bacteria isolated from patients with intra-abdominal infection in our hospital from 2006 to 2010 wereidentified,and their susceptibilty antibiotics were tested and analyzed. RESULTS Totally 158 strains of bacteria were isolated, including 74 （46.84%） strains of gram-positive cocci and 84 （53.16%） strains of gram-negativebacilli l the top six pathogens were Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , Enterococ- cus faecium, Klebsiella pneumoniae ,and S. epidermidis, accounting for 16.45%, 15.19%, 10. 76%, 9.49%,80.86%, and 8.86%, respectiuelyl the positive rates of ESBLs-producing E. coli and K. pneumoniae were 65. 38% and 42.86% ; the drug resistance rates of E. faecium to both vancomycin and linezolid were 6.67% ; the de-tection rates of methicillin-resistant S. aureus （MRSA） and coagulase-negative Staphylococci （MRCNS） were 80. 09% and 74.3 %, respectively, no vaneomycin or linezolid-resistant isolates were detectedl the detection rate of multidrug-resistant P. aeruginosa was as high as 44.1 %, but the resistance rate to cefoperazone/sulbactam wasonly 17.65%. CONCLUSION Gram-negative bacteria occupy as the same proportion as gram-positive bacteria a- mong the pathogens causing nosocomial abdominal infections; it is an important way to treat abdominal infections through the reasonable use of antibiotics in accordance with the result of the surveillance of bacterial resistance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第23期5408-5410,共3页
Chinese Journal of Nosocomiology
关键词
腹腔感染
病原菌
耐药
Abdominal infection
Pathogen
Drug resistance
