摘要
目的 探讨重组人类促红细胞生成素 (rHu -Epo)防治早产儿贫血的疗效。 方法 将 33例早产儿按入院次序分成治疗组 17例 ,对照组 16例。治疗组出生第 1周即予rHu -Epo 5 0 0IU·kg-1·w-1,隔日 1次 ,每周 3次皮下注射 ,共 5周 ;对照组未予rHu -Epo治疗。两组早产儿生后第 3周开始口服铁剂 [元素铁 5mg·kg-1·d-1],必要时输血 ,共观察 7周。结果 治疗组第 2周开始网织红细胞较对照组明显升高 (P <0 0 1) ,第 3周后渐下降但与对照组比较仍有显著差异 (P <0 0 5 ) ;两组患儿出生后Hb均渐下降 ,但治疗组程度较轻 ,最低Hb值较对照组高 (P <0 0 1) ,达最低Hb值的时间较对照组早 (P <0 0 1)。治疗组血清铁蛋白第 2周开始较对照组低 (P <0 0 1)。治疗组输血率与对照组比较明显减少 (P <0 0 5 )。观察期末治疗组早产儿体重增长的速率较对照组高(P <0 0 5 )。结论 早期大剂量rHu -Epo能减轻早产儿贫血的程度 ,减少或避免输血 ;体内充足的铁储备是确保rHu
Objective To evaluate the efficacy of erythropoietin in prevention and treatment of anemia of prematurity.Methods 33 preterm infants were randomly assigned to receive(treated group:17 neonates) or not receive(control group:16 neonates) rHu-Epo.rHu-Epo(500IU·kg -1 ·w -1 )was given three times weekly-one time every 2 days for 5 weeks from the 1st week of life.Both these two groups had oral supplement of elemental iron 5mg·kg -1 ·d -1 from the 15th day of life.Results The initial fall in the reticulocyte counts in treated group had a marked increase compared with the control group (P<0 05).Postnatal decline of hemoglobin(Hb)were lessened in the treated group.The lowest value of Hb was significantly higher in the treated group (P<0 01),the Hb of treated group reached the lowest value earlier than the control group (P<0 01).Serum ferritin dropped more significantly in the treated group during the study period.The need for transfusion in the treated group was significantly less than that in the control group (P<0 05).There were statistically significant differences between these two groups in the rate of weight gain (P<0 05).Conclusion Early administration of high dosage of rHu-Epo can lighten the degree of anemia,reduce or replace the need for blood transfusion.Enough iron supplementation can increase the efficacy of rHu-Epo.
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第6期345-347,共3页
Chinese Journal of Practical Pediatrics
