摘要
以二茂铁二甲酰氯和芳甲酰肼为原料,采用微波法合成了9个N2,N2'-二芳甲酰基-1,1'-二茂铁二甲酰肼类化合物Ⅲ,并通过IR、1HNMR和ESI/MS对其结构进行了表征。紫外光谱研究表明,含吸电子取代基的化合物Ⅲf对阴离子F-、CH3COO-有识别作用,化合物Ⅲh、Ⅲi对F-、CH3COO-、H2PO4-有识别作用。初步的生物活性测试表明,取代基位于邻位的化合物Ⅲa、Ⅲb和Ⅲc对金黄色葡萄球菌、大肠杆菌有良好的抑菌作用。
Nine novel compounds 1, 1 ＇-bis [ （ 2-benzoylhydrazinyl ） carbonyl ] -ferrocene （llI ） were obtained from chlorocarbonyl ferrocene and aromatic formyl hydrazine by using microwave method. The structures of the title compounds have been determined by IR, 1HNMR and ESI/MS techniques. The studies on the UV-Vis absorption spectroscopy show that the anion receptor m f has selective recognition for F-, CH3COO-, and m h, m i for F- , CH3COO- , H2PO4-. Preliminary biological activity test shows that ortho-substituted compounds Ⅲ a, Ⅲb and ]]I c have bacteriostatic action to Staphylococcus aureus and Escherichia coll.
出处
《精细化工》
CAS
CSCD
北大核心
2012年第12期1236-1239,1248,共5页
Fine Chemicals
基金
西安市科技计划项目〔CXY1123(3)〕~~
关键词
酰肼
二茂铁
微波合成
阴离子识别
抑菌活性
精细化工中间体
hydrazide
ferrocene
microwave synthesis
anion recognition
bacteriostatic activity
finechemical intermediates
