摘要
目的观察氟伐他汀(Fluvastatin,Flu)对骨质疏松大鼠血清中Ca2+、Mg2+、P及ALP的影响,探讨其调节骨质疏松无机离子平衡的机制。方法采用雌性大鼠去卵巢法制备骨质疏松大鼠动物模型,同时给予不同剂量的Flu(20、10、5 mg.kg-1)干预,实验12周后测定大鼠血清中碱性磷酸酶(ALP)、Ca2+、P、Mg等的含量。结果 20 mg.kg-1Flu可使骨质疏松大鼠血清中ALP、P水平下降,使Mg2+及Ca2+含量升高(P<0.05,P<0.01);10 mg.kg-1Flu可使骨质疏松大鼠血清中ALP含量下降,Mg2+及Ca2+含量升高(P<0.05,P<0.01);5 mg.kg-1Flu可使骨质疏松大鼠血清中ALP含量降低(P<0.05)。结论 Flu对骨质疏松大鼠血清中的离子代谢失衡具有调节作用。
OBJECTIVE To study the effects of Fluvastatin（Flu）on ALP,P,Mg2＋ and Ca2＋ in the serum of experimental osteoporosis rats,and explore the mechanism how it balance inorganic ions in osteoporosis.METHODS In order to establish the model of osteoporosis,the female rats were ovariectomized.Different doses of Fluvastatin（20,10,5 mg·kg-1） were given to the rats,once daily.After 12 weeks,the levels of ALP,P,Mg2＋ and Ca2＋ in the serum of rats were detected.RESULTS 20 mg·kg-1 Fluvastatin could decrease the serum levels of ALP and P in osteoporosis rat,and could increase the levels of Mg2＋ and Ca2＋（P0.05,P0.01）.10 mg·kg-1 Fluvastatin could decrease the serum levels of ALP in osteoporosis rat,and could increase the levels of Mg2＋ and Ca2＋（P0.05,P0.01）.5 mg·kg-1 Fluvastatin could decrease the serum levels of ALP（P0.05） in osteoporosis rat.CONCLUSION Fluvastatin can regulate the osteoporosis rat＇s ion metabolism balance.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2012年第6期653-655,共3页
West China Journal of Pharmaceutical Sciences
基金
宁夏自然科学基金(NZ10175)
