摘要
目的:观察化疗前应用GnRH类似物-诺雷德对需进行术后辅助化疗并且有维持正常月经要求女性月经复潮的影响。方法:对确诊为乳腺癌并有维持正常月经要求的女性患者随机分成试验组(化疗前应用诺雷德组)和对照组(常规化疗组),比较两组的化疗后的月经来潮情况。结果:21例乳腺癌患者均可完成治疗,化疗后月经周期紊乱。试验组、对照组复潮各为72.7%,50%,P<0.05,差异有显著意义。结论:常规化疗会导致患者提前永久性闭经,月经恢复与年龄相关,化疗前应用诺雷德,可以有效地保护其卵巢功能,维持正常月经。
Objective：To observe the effect of zoladex to protect the ovarian function in the patients with breast cancer requiring for fertility or/and maintenance of normal hormone level before chemotherapy.Methods：Patients with breast cancer requiring for fertility or/and maintenance of normal hormone level were randomly divided into test group and control group.We compared the menstruation status after chemotherapy between the two groups.Results：These 21 breast cancer patients completed the treatment.The rates of the return of menstruation in the test group and the control group were 72.7% and 50%,respectively（P =0.039）.Conclusion：Conventional chemotherapy may lead to permanent amenorrhea in advance and the recovery of menstruation is age-related.Zoladex administered before chemotherapy can effectively protect the ovarian function and fertility or/and maintenance of normal hormone level.
出处
《现代肿瘤医学》
CAS
2012年第12期2501-2503,共3页
Journal of Modern Oncology
关键词
乳腺癌
诺雷德
卵巢功能
化学治疗
breast cancer
zoladex
ovarian function
chemotherapy
