摘要
目的探讨乳腺癌临床病理特点与雌激素受体(ER)、孕激素受体(PR)表达的关系。方法回顾性分析120例乳腺癌患者的临床病理特点,应用免疫组化Elivision法测定乳腺癌组织中ER、PR的表达,并分析临床病理特点与ER、PR表达的关系。结果乳腺癌多发于31～50岁(41.7%)及51～70岁(47.5%);最常见肿瘤类型为浸润性导管癌(78.3%);45.8%患者确诊时已有淋巴结转移;Ⅰ级浸润性导管癌占8.5%,Ⅱ～Ⅲ级占91.5%;ER、PR阴性表达率分别为47.5%、59.2%。Ⅰ级浸润性导管癌ER、PR的阴性表达率均低于Ⅱ～Ⅲ级浸润性导管癌,但差异无统计学意义(P>0.05)。Ⅰ级浸润性导管癌中无一例有脉管内瘤栓和淋巴结转移,而Ⅱ～Ⅲ级浸润性导管癌中脉管内瘤栓和淋巴结转移率分别为(34.9%)和(58.1%)(P<0.01)。结论乳腺癌中ER、PR阴性表达的比例近50%;ER阴性表达与高组织学分级有关;ER阴性表达、高组织学分级易导致淋巴结转移。
Objective To evaluate the relationship between the expression of estrogen receptor （ER） and pro-gesterone receptor （PR） in breast cancer and its clinicopathological features. Methods The data of 120 patients with breast cancer were reviewed retrospectively, the expressions of ER and PR were detected by using Elivision im- munohistochemistry method, and the relationships between the expression of ER and PR in breast cancer and its clinicopathological features were analyzed too. Results The age was mostly between 31-50 years （41.7%） and 51- 70 years （47.5%） ; invasive ductal cancer was the predominant type （76.3%） ; 45.8% of the patients were con- firmed with breast cancer accompanied by lymph node metastasis; of invasive ductal cancer, 8.5% was grade Ⅰ, 91.5% was grade Ⅱ-Ⅲ ; the negative rates of ER and PR were respectively 47.5% and 59.2%. The negative rates of ER and PR in the grade Ⅰ invasive ductal cancer were higher than those in the grade Ⅱ -Ⅲ invasive ductal cancer, but there was no statistical difference （ P 〉 0.05）. No tumor embolus or lymph node metastasis was ob- served in the grade Ⅰ invasive ductal cancer, but the tumor embolus rate and the lymph node metastasis rate were 34.9% and 58.1% in the grade Ⅱ -Ⅲ invasive ductal cancer （P 〈 0.01 ）. Conclusion ER and PR negatively ex- pressed in almost half of breast cancer; the negative expression of ER is related with the high histological grade; the negative expression of ER and high histological grade easily induce lymph node metastasis.
出处
《肿瘤基础与临床》
2012年第6期471-474,共4页
journal of basic and clinical oncology
基金
陕西省卫生科研基金项目(编号:2010C12)
关键词
乳腺癌
病理分型
组织学分级
淋巴结转移
雌激素受体
孕激素受体
breast cancer
pathological type
histological grade
lymph node metastasis
estrogen receptor
progesterone receptor
