摘要
目的观察局限性硬皮病患者血清对T淋巴细胞增殖的影响和患者血清中可溶性白介素-2受体的表达变化。方法应用免疫学方法对39例局限性硬皮病患者血清中的sIL-2R、肿瘤坏死因子(TNF)-α表达和淋巴细胞增殖率进行检测,并与对照组比较。结果局限性硬皮病患者血清可明显降低T淋巴细胞增殖率;局限性硬皮病患者外周血中sIL-2R、TNF-α含量增高,其中活动期增高更加明显;差异均有统计学意义(P<0.05)。结论 T淋巴细胞增殖率的降低和血清中sIL-2R、TNF-α水平表达异常,这些免疫相关细胞和细胞因子可能参与了局限性硬皮病的发生和发展。
Objective To investigate the expression of sIL-2R, TNFct and T-lymphocyte in localized scleroderma. Methods Detected and comparative analysed the serum levels of sIL-2R, TNFct and T-lymphocyte in 39 localized scleroderma patients by immunological methods. Results The serum of patients with localized scleroderma significantly reduced the proliferation oft lymphocytes. The sIL-2R, TNFa levels of peripheral bloOd in localized scleroderma were higher than control group, and active phase increased more significantly than stationary phase （P〈O.05）. Conclusion The reduction of lymphocyte proliferation rate and the abnormal expression of sIL-2R, TNFa may cause the immune dysfunction. During the occurrence and development of localized scleroderma, the immunosuppressive factors maybe involved and maybe one of the precipitating factors.
出处
《实用皮肤病学杂志》
2012年第6期333-335,共3页
Journal of Practical Dermatology
