摘要
目的探讨晚期糖基化终末产物受体蛋白（RAGE）和细胞增殖核抗原（Ki石7）联合评估对结肠癌预后的预测价值。方法检测160例结肠癌标本中RAGE和Ki-67的表达，并分析两者与临床资料及预后的相关性。结果结肠癌组织高表达RAGE和Ki石7；RAGE的表达与肿瘤直径、分化程度、TNM分期和Ki_67的表达密切相关（P〈0．05）；Cox多因素回归分析显示，TNM分期[风险比（OR）：1．99]、Ki-67（OR=1．68）、RAGE（OR=1．62）、Ki-67和RAGE共表达（OR=2．01）是患者的独立预后因素；RAGE和Ki-67双阴性者生存最佳，双阳性者最短，RAGE或Ki-67的阳性者介乎两者之间。结论RAGE和Ki67联合评估可作为结肠癌预后独立预测指标。
Objective To explore the clinical value of combined evaluation of receptor for ad- vanced glycation end products （RAGE） and proliferation cell nuclear antigen （Ki-67） for prognosis of co- lon cancer. Methods A total of 160 patients with colon cancer were chosen for detection of the expression of RAGE and Ki-67. Correlations between the expression and clinicopathologic variables were analyzed. Re- suits The expression of RAGE and Ki-67 was upgraded in colon cancer. The expression of RAGE was closely correlated with tumor size, differentiation, TNM stage and Ki-67 （P 〈0.05）. Multivariate analysis showed that TNM stage （ OR = 1.99）, Ki67 （ OR = 1.68 ）, RAGE （ OR = 1.62）, and co-expression of RAGE and Ki67 （OR = 2. 01 ） were independent prognostic indicators for survival of patients with colon cancer. Patients negative for both Ki-67 and RAGE had the longest survival, those positive for both Ki-67 and RAGE displayed shortest survival, and those positive for either occupied intermediate. Conclusion Combined evaluation of RAGE and Ki-67 expression is a valuable prognostic marker for patients with colon cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2012年第12期2572-2574,F0003,共4页
Chinese Journal of Experimental Surgery
基金
广东省科技计划资助项目（20118031800240）
广东省自然科学基金资助项目（07117381）
关键词
结肠癌
细胞增殖核抗原
预后
Colon cancer
Proliferation cell nuclear antigen
Prognosis
