摘要
目的探讨输尿管上段结石碎石术后泌尿道系统感染常见病原菌及耐药性。方法分离鉴定341例输尿管上段结石碎石术患者中段尿液病原菌,K-B纸片法进行药敏试验。结果 341例患者输尿管上段结石碎石术后泌尿系统感染40例,占11.73%。尿液标本共离出病原菌126株,主要为革兰阴性菌(97株),其中大肠埃希菌39株(30.95%),肺炎克雷伯菌26株(20.63%),铜绿假单胞菌13株(10.31%);革兰阳性菌29株,其中肠球菌12株(9.52%),金黄葡萄球菌10株(7.94%)。大肠埃希菌和肺炎克雷伯菌产ESBLs率分别为30.77%(12株)和26.92%(7株);MRSA菌株5株。主要革兰阴性菌对哌拉西林和亚胺培南敏感;主要革兰阳性菌对万古霉素、氨苄西林和吗啉恶酮敏感。结论输尿管上段结石碎石术后易发生泌尿系统感染,应加强病原菌药敏监测,合理使用抗生素。
Objective To explore the distribution and drug resistance of bacterial infections in patients with upper ureteral calculi after lithotrity.Methods Pathogenic bacteria isolated from samples from 341 patients with upper ureteral calculi after lithotrity at this hospital were analyzed using an ATB identification system and K-B disc diffusion.Results Of the 341 patients,40（11.73%） had a urinary tract infection.In total,126 strains were separated from the urinary tract.The main Gram-negative pathogenic bacteria were Escherichia coli（30.95%）,Klebsiella pneumonia（20.63%）,and Pseudomonas aeruginosa（10.31%）.The main Gram-positive pathogenic bacteria were Enterococcus（9.52%） and Staphylococcus aureus（7.94%）.Of the isolated strains,30.77% were extended-spectrum lactamase-producing E.coli and 26.92% were extended-spectrum lactamase-producing K.pneumonia.There were 5 strains（50.00%） of methicillin-resistant S.aureus.The Gram-positive pathogenic bacilli were sensitive to imipenem and piperacillin.The main Gram-positive bacilli were sensitive to vancomycin,ampicillin,and linezolid.Conclusion Infection is a major complication after lithotrity of upper ureteral calculi.Important steps are to enhance drug resistance surveillance and provide prevention and early treatment.
出处
《中国病原生物学杂志》
CSCD
北大核心
2012年第11期861-863,共3页
Journal of Pathogen Biology
关键词
输尿管上段结石
碎石术
病原菌
耐药性
Upper ureteral calculi
lithotrity
bacterial
drug resistance
