摘要
目的观察银杏叶片联合氯沙坦治疗高血压左心室肥厚以及心率震荡指数的影响。方法纳入高血压左心室肥厚患者120例,随机分成3组:对照组40例,给予钙离子拮抗剂、β-受体阻滞剂(倍他乐克)、阿司匹林等常规基础治疗;氯沙坦组40例,在对照组治疗的基础上加用氯沙坦片(50mg,1次/d);联合组40例,在对照组治疗的基础上给予银杏叶片(19.2mg,3次/d)及氯沙坦(50mg,1次/d),均治疗24个月。观察各组患者治疗前后心率震荡指数〔震荡斜率(TS)、震荡初始心率(TO)〕、左心室质量指标(LVMI)、血压及总胆固醇(TC)等变化。结果与对照组比较,治疗后氯沙坦组及联合组TO、LVMI、收缩压、舒张压显著降低,差异均有统计学意义(F=13.67～34.86,q=4.357～11.321,P<0.05),TS升高,差异均有统计学意义(F=126.58,q=9.701～29.124,P<0.05)。与氯沙坦组比较,联合组TO、LVMI降低,差异均有统计学意义(F=24.18～33.73,q=2.948～3.272,P<0.05),TS显著升高,差异均有统计学意义(F=137.68,q=13.710,P<0.05)。心率震荡指数TO、TS与LVMI呈相关性(r=0.529～0.645,P<0.05)。结论银杏叶片联合氯沙坦可以明显改善高血压左心室肥厚、心率震荡以及自主神经功能紊乱。
Objective To observe the effect of Ginkgo leaf combined with Losartan on left ventricular hypertrophy and heart rate turbulence in hypertensive patient. Methods 120 hypertensive patients with left ventrieular hypertrophy were random- ly divided into three group. Control group： 40 cases, treated with β- blockers, aspirin, and other basic treatment ; Losartan group： 40 cases, basic treatments plus Losartan 50mg, once a day; Ginkgo leaf combined with Losartan combined therapy group： 40 cases, basic treatment plus Ginkgo leaf 19.2rag, three times a day, and Losartan 50mg, once a day. Each group receives a 24 months therapy. Cardiac uhrasonie indexes, HRT parameters, blood pressure and cholesterol were observed. Re- suits Compared with the control group, after treatment with losartan group and combination group TO, LVMI, systolic pres- sure, diastolic pressure is reduced significantly, the differences were statistically significant （ F = 13.67 ～ 34. 86, q = 4. 357 ～ 11. 321, P 〈0. 05 ）,TS increased, the differences were statistically significant （ F = 126. 58, q = 9. 701 ～29. 124, P 〈0.05）. With losartan group, TO, LVMI decreased joint group, the differences were statistically significant （F = 24. 18 ～ 33.73, q = 2. 948 ～ 3. 272, P 〈 0. 05 ）, TS increased significantly, the differences were statistically significant （ F = 137.68, q=13.710, P 〈0.05）. Heart rate turbulence index TO,TS and LVMI significantly correlated （r =0.529 ～0.645, P 〈 0. 05）. Conclusion The combination of Ginkgo leaf and Losartan can improve LVH and HRT parameters of hypertension, as well as the damage of autonomic nervous system.
出处
《实用心脑肺血管病杂志》
2012年第12期2007-2009,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
银杏叶片
氯沙坦
高血压
肥大
左心室
心率震荡
Ginkgo leaf
Losartan
Hypertension
Hypertrophy, left ventficular
Heart rate turbulence
