摘要
目的:探讨川芎嗪治疗急性胰腺炎的可能机制。方法:60例轻症急性胰腺炎(MAP)患者随机分为川芎嗪组和对照组,每组30例。对照组予以常规治疗,川芎嗪组加用川芎嗪针100mg加入5%葡萄糖液500ml中静滴,1次/d,10d一个疗程。结果:两组患者治疗前血浆TNF-α、IL-6含量基本一致(P>0.05);治疗一个疗程后,川芎嗪组血浆TNF-α、IL-6含量及TXA2/PGI2比值均明显低于对照组(均P<0.05)。川芎嗪组痊愈率、总有效率均明显高于对照组(均P<0.05)。结论:调节胰腺炎患者外周血TNF-α、IL-6浓度及TXA2/PGI2比值可能是川芎嗪治疗AP的主要机制。
Objective To investigate the possible mechanism of ligustrazine in treating acute pacreatitis（AP）.Methods Sixty patients with minor acture pancreatitis（MAP） were randomly divided into the ligustrazine and control groups,with 30 patients in each group.In the control group,the subjects underwent conventional therapy,while in the ligustrazine group,the patients were administered with ligustrazine（100 mg with 5% glucose solution 500ml,iv.gtt） once a day,10 days as a course.Results There was no real significant differences in serum TNF-α,IL-6 in two groups（P0.05）,while after one course of therapy,the TNF-α,IL-6 levels and TXA2/PGI2 ratio in the treatment group decreased significantly than those in the control group（P0.05）.The curable rate and total effective rate increased obviously in the ligustrazine group compared with the control group（all P0.05）.Conclusion The major mechanism of ligustrazine in treating AP might be its regulation of peripheral blood serum TNF-α,IL-6 levels and TXA2/PGI2 ratio.
出处
《放射免疫学杂志》
CAS
2012年第6期643-645,共3页
Journal of Radioimmanology
基金
浙江省文成县科技项目编号201185
