摘要
目的:探讨酒精性肝硬化患者血清TGF-β1水平与脂质过氧化的相关性。方法:应用放射免疫分析和化学法对36例酒精性肝硬化患者进行了血清TGF-β1和SOD、MDA检测,并与35名正常健康人作比较。结果:酒精性肝硬化患者血清TGF-β1、MDA水平非常显著地高于正常人组(P<0.01),而血清SOD水平又非常显著地低于正常人组(P<0.01)。血清TGF-β1水平与MDA水平呈正相关(r=0.6138,P<0.01),而与SOD水平呈负相关(r=-0.3784,P<0.01)。结论:检测酒精性肝硬化患者血清TGF-β1和SOD、MDA水平的变化对于了解病情、观察疗效和病后判断均具有一定的临床实用价值。
Objective To explore the relationship between serum TGF-β1 and SOD, MDA levels in patients with alcoholic cirrhosis. Methods Serum TGF-β1 （with RIA）, serum SOD,MDA（with chemistry） levels were measured in 36 patients with alcoholic cirrhosis and compared with 35 normal healthy controls. Results Serum TGF-β1 ,MDA levels were significantly higher than those in controls（P 〈0.01 ）. But serum SOD level was markedly lower（P 〈0.01 ） ,serum TGF-β1 level was positively correlate with MDA level（r =0.6138,P〈0.01）,serum TGF-β1 level was negatively correlated with SOD level（r= -0.3784,P〈0.01）.Conclusion Changes of serum TGF-β1 , SOD, MDA levels might be of certain clinical value for mornitoring therapeutic effects and prognosis in patients with alcoholic cirrhosis.
出处
《放射免疫学杂志》
CAS
2012年第6期625-626,共2页
Journal of Radioimmanology
关键词
酒精性肝硬化
转化生长因子Β1
脂质过氧化
超氧化物歧化酶
丙二醛
alcoholic cirrhosis, transforming growth factor-β1 （ TGF-β1 ）, lipid peroxidation, superoxide dismutase （ SOD）, malonaldehyde （ MDA ）
