摘要
目的介绍白介素-1β(IL-1β)的概况及其与胃癌关系的研究进展。方法收集近年来国内、外关于IL-1β及其与胃癌关系的相关文献并进行综述。结果 IL-1β是一种促炎性细胞因子,可以介导炎症发生、调节免疫反应、诱导基因发生表观遗传学改变等,在胃癌组织中高表达。影响IL-1β在胃癌组织中表达水平的因素包括IL-1β的基因多态性、核因子-κB的干预和幽门螺旋杆菌感染。IL-1β可以抑制胃酸分泌、诱导DNA发生甲基化改变、募集骨髓源细胞、促进胃癌血管形成及促进血管细胞黏附分子-1、细胞间黏附分子-1、CD44等黏附分子的表达,在胃癌的发生、发展和转移中均发挥了重要作用。结论靶向性地阻断IL-1β及其受体具有抑制胃癌发生的作用,有望成为胃癌治疗新的策略之一。
Objective To introduce the overview about interleukin-1β（IL-1β）and the advance in research on relation between IL-1β and gastric cancer.Method Relevant literatures in recent years about IL-1β in gastric cancer were collected and analyzed.Results IL-1β,a proinflammatory cytokine which was overexpressed in gastric cancer tissues,mediated reaction of inflammatory cells and induced the epigenetics of gene.The factors influencing the expression of IL-1β included IL-1β gene polymorphism,nuclear factor-κB intervention,and Helicobacter pylori infection.IL-1β played an important role in the incidence,development,and prognosis of gastric cancer by inhibiting gastric acid secretion,DNA methylation,collecting bone marrow derived dendritic cells,regulating the formation of vessel,and promoting vascular cell adhesion molecule-1,intercellular adhesion molecule-1,and CD44 expressions.Conclusion Targeted to block IL-1β and IL-1β receptor can be used as one of the new anti-tumor strategy because of their tumor suppression in the future.
出处
《中国普外基础与临床杂志》
CAS
2012年第11期1249-1254,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金项目(项目编号:30870364)
兰州大学"中央高校基本科研业务费专项基金"(项目编号:lzujbky-2011-t03)~~
关键词
胃癌
白介素-1Β
幽门螺旋杆菌
Gastric cancer
Interleukin-1β
Helicobacter pylori
