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甲磺酸伊马替尼的合成 被引量:2

Synthesis of Imatinib Mesylate
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摘要 以3-乙酰吡啶为起始原料,通过缩合、环化、酰化等反应制备了甲磺酸伊马替尼,产物纯度为99.4%、总收率为30%。反应中间体及产物结构经核磁共振氢谱确证。 Imatinib mesylate was prepared from 1- (pyridine-3-yl) ethanone by condensation, cyclization, acy- lation. The purity and overall yield of the product was 99.4% ,30% ,respectively. The structure of the interme- diates and product were identified by 1HNMR.
作者 刘娥
出处 《化学与生物工程》 CAS 2012年第11期36-38,共3页 Chemistry & Bioengineering
基金 荆楚理工学院项目(ZR201007)
关键词 甲磺酸伊马替尼 3-乙酰吡啶 合成 imatinib mesylate 1- (pyridine-3-yl) ethanone synthesis
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