摘要
以3-乙酰吡啶为起始原料,通过缩合、环化、酰化等反应制备了甲磺酸伊马替尼,产物纯度为99.4%、总收率为30%。反应中间体及产物结构经核磁共振氢谱确证。
Imatinib mesylate was prepared from 1- (pyridine-3-yl) ethanone by condensation, cyclization, acy- lation. The purity and overall yield of the product was 99.4% ,30% ,respectively. The structure of the interme- diates and product were identified by 1HNMR.
出处
《化学与生物工程》
CAS
2012年第11期36-38,共3页
Chemistry & Bioengineering
基金
荆楚理工学院项目(ZR201007)
关键词
甲磺酸伊马替尼
3-乙酰吡啶
合成
imatinib mesylate
1- (pyridine-3-yl) ethanone
synthesis