摘要
目的比较帕罗西汀与氯丙咪嗪治疗强迫症的临床效果及不良反应。方法将2009～2011年间收治的108例强迫症患者随机分为2组,每组各54例,一组运用帕罗西汀治疗,另一组运用氯丙咪嗪治疗,观察两组患者的临床疗效和不良反应。结果两组患者治疗后Yale-Brown强迫量表评分较治疗前有显著改善(P<0.05);治疗后4周和8周的Yale-Brown强迫量表评分两组之间的差异无统计学意义(P>0.05)。帕罗西汀组患者治疗8周后总有效率为64.8%,低于氯丙咪嗪组的68.5%,组间差异无统计学意义(P>0.05)。帕罗西汀组患者不良反应发生率为7.4%,氯丙咪嗪组患者不良反应发生率为22.2%,两组间不良反应率之间的差异有统计学意义(P<0.05)。结论帕罗西汀治疗强迫症与氯丙咪嗪疗效相当,但不良反应发生率低,患者耐受性好,值得临床推广。
Objective To compare clinical effects and adverse reactions of paroxetine and clomipramine in treatment of obsessive compulsive disorder.Methods 108 patients with OCD in our hospital from 2009 to 2011 years were randomly divided into 2 groups,54 cases in each group,one group were accepted the paroxetine treatment,another group were accepted clomipramine treatment.Clinical effect and adverse reaction of patients in two groups were observed.Results After treatment YaleBrown Obsessive-Compulsive Scale score signif icantly improved than before（P 0.05）,while the difference of the YaleBrown Obsessive-Compulsive Scale score after4 and 8 weeks between two groups was not statistically signif icant（P0.05）.Patients in paroxetine group after 8 weeks treatment the total effective rate was 64.8%,slightly lower than clomipramine group 68.5%,the difference between two groups was not statistically significant（P0.05）.Adverse reaction rate of patients in paroxetine group was 7.4%,adverse reaction rate of patients in clomipramine group was 22.2%,the difference of adverse reaction rate among the two groups was statistically significant（P0.05）.Conclusion Paroxetine in treatment of obsessive compulsive disorder has good clinical eff icacy as clomipramine,but has a low incidence of adverse reactions,patient tolerance is good,worthy of clinical application.
出处
《当代医学》
2012年第35期23-24,共2页
Contemporary Medicine
关键词
强迫症
帕罗西汀
氯丙咪嗪
临床疗效
Obsessive compulsive disorder
Paroxetine
Clomipramine
Clinical curative effect
