摘要
目的探讨颈动脉狭窄程度与同侧脑区ADC值间的相关性。方法收集经颈动脉三维对比增强磁共振血管成像证实颈动脉狭窄者116例和正常志愿者21例行T2FLAIR和DWI检查,测量多脑区ADC值并分析狭窄程度与ADC值的相关性,P<0.05为有统计学意义。结果颈动脉狭窄程度与侧脑室前部(r=0.260,P=0.000)、后部(r=0.149,P=0.014)、前角(r=0.194,P=0.001)、后角(r=0.188,P=0.002),周围脑实质、颞叶(r=0.186,P=0.002)及尾状核头(r=0.125,P=0.039)等脑区ADC值间相关性有统计学意义。结论多脑区ADC值升高与颈动脉狭窄有关,以侧脑室前部周围脑实质相关性最高,可视为间接反映低灌注状态的最敏感区域。
Objective To investigate the relations between ADC values of interested cerebral regions and carotid stenosis using diffusion-weighted imaging and MR angiography. Methods 116 cases of carotid stenosis and 21 cases of matched healthy controls were recruited in this study on the basis of three-dimensional contrast enhanced MR angiography （MRA） of carotid artery and were checked with DWI and T2 FLAIR. ADC values of interested regions were measured on DWI （b 0,1 000 s/mm2） images. The relationship between carotid stenosis and ADC values were analysed, P d0.05 is of sta- tistical significance. Results The ADC values around anterior （ r =0. 194, P =0. 001） and posterior horn （ r =0. 188, P =0. 002） of lateral ventricle and the ADC values of periventrieular anterior （ r =0. 260, P =0. 000） and posterior （ r 0. 149, P =0. 014）, the temporal lobe （ r =0. 186, P =0. 002） and the caudate nucleus head （ r =0. 125, P=0. 039） were positively linearly correlated with the degree of stenosis with 274 branches of carotid arteries. Conclusion ADC val- ues in the majority of cerebral regions positively correlated with the severeness of carotid stenosis. Especially, ADC values of periventricular anterior was most closely related to the carotid stenosis, which was most sensitive for hypoperfusion.
出处
《医学影像学杂志》
2012年第11期1791-1794,共4页
Journal of Medical Imaging
关键词
颈动脉狭窄
扩散加权成像
磁共振血管成像
低灌注脑白质改变
Carotid stenosis
Diffusion-weighted imaging
MR angiography
Hypoperfusion related white matter chan- ges
