摘要
目的检测2型糖尿病并发冠心病患者血清白介素-6浓度的变化并探讨其临床意义。方法将150例患者根据冠状动脉造影结果分为2型糖尿病组(46例)、冠心病组(52例)、2型糖尿病并发冠心病组(52例);同时选取50例正常对照者分别测定血清白介素-6浓度和其他临床指标,并作对比分析。结果与正常对照组相比,2型糖尿病组、冠心病组及2型糖尿病并发冠心病组血清白介素-6水平均明显升高(P<0.01);2型糖尿病并发冠心病组较2型糖尿病组及冠心病组亦升高(P<0.01);2型糖尿病组、冠心病组间差异无统计学意义(P>0.05);logistic回归分析显示白介素-6及糖化血红蛋白进入回归方程,二者OR值分别为4.062、7.642;双变量相关分析显示白介素-6与Gensini积分存在显著相关性(r=0.740,P<0.01)。结论血清白介素-6浓度可能对预测2型糖尿病并发冠心病有重要意义。
Objective To investigate the changes and significance of serum IL-6 in type 2 diabetic patients with coronary heart disease.Methods Based on the results of coronary angiography,cases were divided into normal control group（n=50）,Type 2 diabetes mellitus group（T group,n=46）,coronary heart disease group（C group,n=52） and Type 2 diabetes mellitus with coronary heart disease group（TC group,n=52）.The serum IL-6 level and other clinical indexes of all cases was detected.Results The levels of serum IL-6 in T,C and TC groups were significantly higher than that in the normal control group.Moreover,the serum IL-6 level in TC group was higher than that in T and C groups（P0.01）.There was no significant difference of serum IL-6 level between T and C groups..Logistic regression analysis showed that the detection of serum IL-6 and HbA1c entered into the Logistic regression equation and the OR values were 4.062 and 7.642,respectively.The divariant correlation analysis indicated that there was significant correlation between serum IL-6 and the Gensini score.Conclusion Serum IL-6 level may play an important role in predicting Type 2 diabetes mellitus with coronary heart disease.
出处
《遵义医学院学报》
2012年第3期213-216,共4页
Journal of Zunyi Medical University
关键词
白介素-6
2型糖尿病
冠心病
Interleukin-6
type 2 diabetes mellitus
coronary heart disease
