摘要
目的:探讨活血潜阳方对高血压(血瘀阳亢痰浊证)合并胰岛素抵抗患者血压、胰岛素抵抗及生活质量的影响。方法:临床收集60例高血压合并胰岛素抵抗(血瘀阳亢痰浊证)的患者,随机分为贝那普利组及贝那普利加用活血潜阳方组,按各组要求给药治疗8周,临床观察各组患者的血压、胰岛素敏感及抵抗指数、临床症状积分,并检测患者治疗前后焦虑自评量表(SAS)、抑郁自评量表(SDS),通过比较上述指标的差异,来比较两组治疗对患者血压及生活质量的影响。结果:①两组治疗均能有效降低血压(P<0.01),活血潜阳方组对舒张压的降低疗效优于贝那普利组(P<0.05)。②活血潜阳方组的治疗能明显改善患者的临床症状积分(P<0.01),与贝那普利组相比积分前后下降值间存在统计学差异(P<0.05),临床症状的有效率优于贝那普利组(P<0.05)。③两组的治疗均可降低患者的SAS积分与SDS积分(P<0.01)。活血潜阳方组对患者的SAS积分下降的效果优于贝那普利组(P<0.01)。④活血潜阳方组的治疗能明显降低患者的空腹胰岛素水平(P<0.01),并随以上指标的改善,胰岛素敏感指数显著升高,胰岛素抵抗指数明显下降,治疗前后自身对照存在统计学差异(P<0.05)。结论:高血压兼有血瘀阳亢痰浊证患者存在明显的胰岛素抵抗,联用活血潜阳方治疗高血压合并胰岛素抵抗(血瘀阳亢证)的患者较单用西药贝那普利能更有效的降低血压及胰岛素抵抗,改善临床症状,缓解患者的焦虑状态,显著改善患者的生活质量。因此,活血潜阳方是治疗高血压的有效方剂。
Objective：To explore effects of Huoxue Qianyang Formula（XHQYF）on the blood pressure,insulin resistance and the quality of life of patients with essential hypertension of blood stasis Yang hyperactivity turbid phlegm syndrome.Methods：In clinical trials,sixty cases of patients with hypertension and insulin resistance（blood stasis and Yang hyperactivity and turbid phlegm syndrome）were randomly and equally divided into Benazepril treated group and HXQYF combined with Benazepril treated group for 8 weeks of treatment.Before and after treatment,the blood pressure（BP）,insulin sensitivity and insulin resistance,clinical symptoms scores（CSS）,the scores of self-rating anxiety scale（SAS）and self-rating depression scale（SDS）were observed.By comparing the above indexes,the effects on BP and the quality of life were compared between the groups.Results：①Two groups of treatment can effectively lower blood pressure（P〈0.01）,Huoxue Qianyang Formula group can reduce diastolic blood pressure more effectively than benazepril group（P〈0.05）.②Huoxue Qianyang Formula group can significantly improve the clinical symptom score（P〈0.01）,the score reduced more than the benazepril group before and after therapy（P〈0.05）.③Both treatment of two groups can reduce the score of SAS and SDS（P 0.01）.The effectivity of Huoxue Qianyang Formula group to reduce the score of SAS is superior to that of benazepril group（P〈0.01）.④Huoxue Qianyang Formula group can significantly reduce the patient＇s fasting insulin levels（P〈0.01）,and with the improvement of the above indicators,the increase of insulin sensitivity index and the decrease of insulin resistance index were significant（P〈0.05）.Conclusion：Essential Hypertension with blood stasis and Yang hyperactivity and turbid phlegm syndrome has marked insulin resistance.Treatment of Huoxue Qianyang Formula combined with Benazepril can lower blood pressure,improve clinical symptoms,relieve anxiety and improve the quality of life
出处
《辽宁中医杂志》
CAS
2012年第11期2190-2194,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
上海市自然科学基金(10ZR1431100)
上海岳阳中西医结合医院院级课题项目
关键词
高血压病
血瘀阳亢痰浊
胰岛素抵抗
中医药治疗
焦虑抑郁状态
essential hypertension
blood stasis and Yang hyperactivity and turbid phlegm
insulin resistance
traditional chinese medicine treatment
anxiety-depression
