摘要
目的对2型糖尿病与胆囊炎相关因素进行分析,探讨其发病机制。方法 241例2型糖尿病患者均行腹部多普勒超声检查以明确胆囊炎诊断,分为合并组:2型糖尿病合并胆囊炎患者105例,糖尿病组:2型糖尿病不合并胆囊炎患者136例;所有对象均测量身高、体重、腰围、臀围,计算体重指数(BMI)、腰臀围比(WHR),检测血脂、糖化血红蛋白(HbA1c),行糖尿病眼底及四肢神经及感觉振动阈值检查。结果 BMI合并组(25.78±2.37)、糖尿病组(23.62±4.15),两组相比差异有统计学意义(P<0.05);合并组血胆固醇(2.78±0.56)mmol/L、甘油三酯(5.50±0.96)mmol/L及低密度脂蛋白胆固醇(3.71±1.36)mmol/L与糖尿病组血胆固醇(2.04±0.41)mmol/L、甘油三酯(4.61±0.73)mmol/L及低密度脂蛋白胆固醇(3.14±1.22)mmol/L相比增高,而合并组高密度脂蛋白胆固醇(0.91±0.71)mmol/L与糖尿病组(1.26±0.40)mmol/L相比显著降低;合并组HbA1c(10.01±2.56)%和微血管(74.29%)及周围神经病变(59.05%)发生率均明显高于糖尿病组HbA1c(8.55±2.31)%、微血管(47.06%)及周围神经病变(24.26%)发生率。结论 2型糖尿病患者易患胆囊炎与高血糖、血脂代谢紊乱、微血管及神经病变有关,积极控制血糖、调节血脂及治疗血管、神经并发症是降低2型糖尿病患者胆囊炎发病率的关键。
OBJECTIVE To analyze the correlation between type 2 diabetes and cholecystitis and explore its pathogenesis.METHODS A total of 241 patients with type 2 diabetes were performed abdominal doppler ultrasound to clear cholecystitis diagnosis.There were 105 patients with type 2 diabetes complicated by cholecystitis and 136 patients with type 2 diabetes without merging cholecystitis.The height,weight,waist and hip circumference,body mass index（BMI）,waist-hip ratio（WHR）,serum lipids,glycosylated hemoglobin（HbA1c）,diabetes line eyes and limbs,nerves and sense of vibration threshold of all the participants were measured.RESULTS The BMI（25.78±2.37）,TC（2.78±0.56） mmol/L,TG（5.50±0.96） mmol/L,LDL-C（3.71±1.36） mmol/L,HbA1c（10.01±2.56）% and microvascular（74.29%） and peripheral neuropathy（59.05%） of the patients with diabetes combined with cholecystitis were significantly higher than BMI（23.62±4.15）,TC（2.78±0.56） mmol/L,TG（4.61±0.73） mmol/L,LDL-C（3.14±1.22） mmol/L,HbA1c（8.55±2.31） %and microvascular（47.06%） and peripheral neuropathy（24.26%） of the patients with diabetes without emerging cholecystitis（P0.05）.HDL-C（0.91±0.71） of the patients with diabetes combined with cholecystitis was significantly lower than HDL-C（1.26±0.40） of the patients with diabetes without emerging cholecystitis.CONCLUSION The patients with type 2 diabetes are prone to cholecystitis,which is related to the high blood glucose,dyslipidemia,microvascular and neuropathy.Active control of blood sugar,regulation of blood lipids,and treatment of vascular and neurological complications are crucial to reduce the incidence of cholecystitis in the patients with type 2 diabetes.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第22期5023-5024,共2页
Chinese Journal of Nosocomiology
关键词
糖尿病
胆囊炎
血脂异常
Diabetes mellitus
Cholelithiasis
Dyslipidemias
