摘要
目的:观察小剂量米非司酮治疗子宫肌瘤临床效果和安全性。方法:2010年11月至2011年10月子宫肌瘤患者72例随机分为两组,A组按5mg/d,B组按2.5mg/d服用米非司酮,3个月为1个疗程。用药结束后复诊,行彩超检查子宫肌瘤的三维径线半径计算肌瘤体积,同时观察不良反应以判定用药安全性。结果:各组患者肌瘤体积均均明显缩小,平均缩小24%～45%。A组有效26例,有效率达81.25%,B组有效31例,有效率达77.5%。两组患者疗效和不良反应无统计学差异(P>0.05)。结论:小剂量(2.5mg/d)米非司酮治疗子宫肌瘤疗效肯定,安全性高,减轻了患者的经济负担。
Objective:To observe the clinical effects and safety on two kinds of low-dose mifepristone.Method:From 2010 November to 2011 October,seventy-two women from our hospital on termination of Uterine Leiomyoma were randomly divided into two groups:A group of 5mg/d, and B group of 2.5mg/d for taking a course of 3 months.Examination the 3D line radius and calculation the volume of uterine leiomyoma by using color doppler ultrasound after stopping taking medicine. At the same time,we will observe adverse reaction to determinate the safety of the drug.Results:Both of uterine leiomyoma volume were significantly reduced,and an average of 34% to 45%smaller.Effect of group A in 26 cases,the effective rate was 81.25%;in B group,effective in 31 cases,the effective rate was 77.5%.Effects and adverse reactions of two groups were similar.Conclusions:Low-dose(2.5mg/d) mifepristone treatment of uterine leiomyoma is effective than the security,and reduces the economic burden of patients.
关键词
米非司酮
子宫肌瘤
疗效
不良反应
肝功能
Mifepristone
Uterine Leiomyoma
Effects
Adverse reaction
Liver function
