摘要
DC作为专职的抗原呈递细胞,在启动和调节先天性及适应性免疫应答中发挥关键性作用。芳香烃受体(arylhydrocarbon receptor,AhR)作为配基依赖性活化转录因子,可表达于树突状细胞(dendritic cell,DC)中。AhR与不同配体相结合活化后,可通过对DC的影响调节机体免疫应答。深入研究AhR和DC的关系的为纠正DC功能异常所导致的免疫功能紊乱提供新的思路。本文就AhR与DC来源、分化、成熟以及介导的免疫应答之间的关系作一简要综述。
Dendritic cells（DCs）,as professional antigen presenting cells,play a critical role in immune response.While aryl hydrocarbon receptor（AhR）,as a transcription factor,is expressed in dendritic cells（DC）.AhR is activated following binding to ligands and regulates immune response through DC.Therefore,the investigation of the relationship between AhR and DC would provides a new prospect for the recovery of immune system functional disorder induced by DC dysfunction.In this paper,we reviewed the association of AhR with DC resource,differentiation,maturation,and immune response.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2012年第12期1094-1098,共5页
Immunological Journal
基金
国家青年基金项目(81001320)
关键词
AHR
DC
免疫应答
Aryl hydrocarbon receptor
Dendritic cell
Immune response
