摘要
目的观察趋化因子受体(CXC chemokine receptor-4,CXCR4)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在上皮性卵巢癌中的表达及其相关性。方法应用免疫组化SABC法检测40例浆液性和黏液性卵巢癌、10例浆液性和黏液性卵巢囊腺瘤、9例卵巢癌盆腔腹膜转移灶及10例正常卵巢组织中CXCR4和VEGF的表达。结果 CXCR4在卵巢癌原发灶及转移灶中均呈高表达,阳性率分别为57.5%、88.9%,明显高于正常卵巢组织及卵巢良性肿瘤中的表达。VEGF在卵巢癌及转移灶中均呈高表达,阳性率分别为72.5%、100%,明显高于正常卵巢组织及卵巢良性肿瘤。CXCR4、VEGF在上皮性卵巢癌中的表达呈正相关(P<0.05)。结论 CXCR4、VEGF在上皮性卵巢癌中及转移灶中的阳性率较高,且两者的表达呈正相关。提示CXCR4、VEGF在上皮性卵巢癌的发生和转移中起重要作用。
Purpose To study the expression of CXCR4 and VEGF in human epithelial ovarian cancer and to explore their relation- ship. Methods 40 cases with ovarian serous or mucious cancer, 10 cases with benign serous or mucious epithelial tumor, 9 cases with peritoneal metastasis and 10 eases with ovarian normal tissues were investigated. Immunohistochemestry was used to detect the ex- pressions of CXCR4 and VEGF. Results CXCR4 protein expressed positively was 57.5% in ovarian cancer, 88. 9% in peritoneal metastasis, which wer~ higher than those with benign epithelial tumor and normal ovarian tissue. The positive expressions of VEGF was 72. 5% in ovarian cancer and was 100% in peritoneal metastasis, which were higher than those with benign epithelial tumor and normal ovarian tissue. There was positive correlation between CXCR4 and VEGF expressions in malignant epithelial ovarian tumor （P 〈 O. 05 ）. Conclusion The higher expression of CXCR4 and VEGF and their positive correlationship in epithelial ovarian cancer suggest up-regulation of the two proteins may play a role in the pathogenesis and metastasis of human epithelial ovarian cancer.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2012年第11期1220-1223,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
邯郸市科学技术研究与发展计划项目(1123108146)
