摘要
目的分析儿童和青少年偏头痛患者的流行病学,并观察氟桂利嗪预防性治疗疗效。方法根据我院儿科儿童和青少年期偏头痛患者(n=200)的临床症状、体征、病史、辅助检查、偏头痛及其可能发病诱因的相关问卷,分析偏头痛的分型、临床特征及可能的诱因,并以偏头痛发作频率和头痛程度评价氟桂利嗪(一日1次10 mg)睡前服用治疗8周的疗效。结果 200例入选患者按偏头痛分型依次为:无先兆性偏头痛112例(56.0%),有先兆性偏头痛患者43例(21.5%),周期性综合征26例(13.0%),视网膜偏头痛11例(5.5%),其他类型患者8例(4.0%)。学习紧张(42.0%)和人际关系不睦(约28.0%)等是最常见的诱发因素。患者接受氟桂利嗪治疗后,偏头痛发作频率和头痛程度与治疗前相比改善显著(P<0.01)。结论偏头痛分型、临床特征及诱因等某些特性有助于临床儿童和青少年偏头痛鉴别诊断,且氟桂利嗪预防性治疗儿童和青少年偏头痛有效,值得临床推广。
Objective To analyze the epidemiological characteristics of migraine in children and adolescents and to observe the efficacy of the preventive treatment with flunarizine.Methods Based on the clinical symptoms,signs,medical history and auxiliary examination of migraine,the clinical characteristics,predisposing factors and classification of migraine in children and adolescents were analyzed.Those patients were administrated with flunarizine 10 mg orally once a day for eight weeks.Results Totally 200 migraine patients with clinical diagnosis were identified as migraine without aura for 56.0%,migraine with aura for 21.5%,periodic syndrome for 13%,retinal migraine for 5.5% and others for 4.0%.Among them tense learning（42.0%） and interpersonal discord（28.0%） were the most common predisposing factors.Seizure frequency and degree of migraine were decreased significantly after therapy with flunarizine.Conclusion The clinical characteristics,predisposing factors and classification may benefit to migraine identified.The flunarizine for migraine prophylactic treatment is effective and safe.
出处
《世界临床药物》
CAS
2012年第11期670-673,共4页
World Clinical Drug
关键词
儿科
偏头痛
流行病学
预防性治疗
氟桂利嗪
pediatric department
migraine
epidemiology
preventive treatment
flunarizine
