摘要
目的:比较抗抑郁药氟西汀和草酸艾司西酞普兰治疗老年抑郁症后抑郁症状的改善以及不良反应的分析。方法:将64例符合中国精神障碍分类与诊断标准第三版诊断标准的老年期抑郁症患者随机平分为两组,分别给予氟西汀和草酸艾司西酞普兰治疗6周。治疗前和治疗后2、4、6、8周末分别采用汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)评定疗效和不良反应。结果:1.第1周草酸艾司西酞普兰组的症状明显轻于氟西汀组(P<0.01),第2周末两组HAMD减分率无显著差异。2.经过6周治疗后,草酸艾司西酞普兰组和氟西汀组的有效率分别为85.58%、84.26%,治愈率分别为52.6%、49.8%,两组的有效率和治愈率差异不显著。3.两组不良反应比较,草酸艾司西酞普兰的不良反应更轻微。结论:草酸艾司西酞普兰与氟西汀对老年抑郁症患者有肯定疗效,不良反应小;草酸艾司西酞普兰起效更快,不良反应更轻微,老年患者对其的依从性更好。
Objective：To study the effect and safety of Fluoxetine and Escitalopram Oxalate treating the old with depression. Methods：Sixty -four old patients with depression which diagnosed with CCMD -3 were randomly divided into a Fluoxetine group with 32 patients treated by Fluoxetine, and a Escitalopram Oxalate group with 32 patients treated by Escitalopram Oxalate . The treatment lasted for 6 weeks. The HAMD and the TESS were used to assess the effect and safety, depression and the side effect of before and 1, 2, 4, 6, weeks after treatment. Results： 1. The scores of HAMD of Escitalopram Oxalate group were significantly lower than that of Fluoxetine group after 1 weeks＇treatment （P 〈 O. O1 ） ,The scores of HAMD between two groups were insignificantly after the two week treatment. 2. After 6 weeks treatment, the effective power of Escitalopram Oxalate group and Fluoxetine group was 85.58% ,84.26% , the cure rate of two groups was 52.6% ,49.8% , the effective power and the cure rate of two groups were insignificantly. 3. the side effect of Escitalopram Oxalate group was lighter than Fluoxetine group. Conclusions： Fluoxetine and Escitalopram Oxalate were more effective and safety to cure the old with depression. But Eseitalopram Oxalate is seem to have effects earlier than Fluoxetine, and the side effect of Escitalopram Oxalate was lighter than Fluoxetine . The old may have good compliance.
出处
《中国民康医学》
2012年第21期2579-2580,共2页
Medical Journal of Chinese People’s Health
