摘要
目的总结结膜黏液瘤和血管黏液瘤的临床病理学特点。方法回顾性系列病例研究。对2005年1月至2010年12月天津市眼科医院收治的3例结膜黏液瘤和2例血管黏液瘤患者的临床和组织病理学资料进行归纳分析。病理学检查采用常规石蜡切片，HE染色和Vimentin、CD34、SMA、S-100免疫组织化学染色。结果5例患者中，男性2例，女性3例；年龄40—74岁，平均年龄（55．8±14．8）岁。临床表现为球结膜黄粉色实性或半透明的囊性肿物，其中2例发生于颞侧球结膜，1例发生于鼻侧球结膜，1例发生于鼻侧角结膜缘周围并侵及角膜，另外1例为鼻侧、颞侧和下方球结膜下多发性肿物。5例患者均在局部麻醉下行肿物切除术，其中2例肿物有较薄的纤维膜。病理学检查结果显示，3例黏液瘤主要由稀疏散在的小卵圆形细胞、梭形细胞、星芒状细胞和大量的黏液样物质组成，血管稀少。2例血管黏液瘤除上述特点外，肿瘤组织内有许多小血管或毛细血管。免疫组织化学染色结果显示，肿瘤细胞对Vimentin抗体呈阳性反应，而对S-100蛋白抗体呈阴性反应；部分肿瘤细胞对CD34和SMA抗体呈阳性反应。术后4例获得随访，其中1例于术后1个月复发。结论结膜黏液瘤和血管黏液瘤多表现为局限性黄粉色实性或半透明的囊样肿物，少数为多发性。手术完整切除是首选治疗方法。
Objective To explore the clinical and pathological features of conjunctival myxoma and angiomyxoma. Methods It was a retrospective ease series study. The clinical and pathological features of 3 cases of conjunctival myxoma and 2 eases of conjunctival angiomyxoma were analyzed. These cases were treated from January 2005 to December 2010 at Tianjin Eye Hospital. Routine pathological examinations and immunohistochemical staining were performed, including staining for Vimentin, S-IO0, SMA and CD34. Results In the 5 patients, 2 eases were male and 3 eases were female. The mean age was （55.8 ± 14.8） years, ranging from 40 to 74 years. The tumors presented as yellow-pink, translucent, cystic and （or） with solid masses. Regarding the tumor location, 2 cases involved the temporal side, 1 case involved the nasal side, 1 case involved the nasal limbus and invaded the cornea, and 1 case involved the nasal, temporal and inferior parts. The lesions of the 5 cases were excised under local anaesthesia. Histopathological examination revealed that the conjunetival myxomas were composed of abundant mucoid material and relatively small numbers of small, ovoid, spindle and stellate shaped cells with sparse vessels. The histologic features of the conjunctival angiomyxoma were similar to those of myxomas with the exception of the former being characterized by a prominent vascular structure. The immunohistochemical staining showed that tumor cells were positive for Vimentin, but negative for S-100 protein; some tumor cells were positive for CD34 and SMA. The fallow-up was performed in 4 cases post-operation. One case experienced recurrence 1 month after surgical excision. Conclusions Most of the conjunctival myxoma and angiomyxoma appear as a local yellow-pink, translucent, cystic and （or） with solid mass, and some of which had multiple tumors. The preferred management route is complete surgical excision.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2012年第11期981-984,共4页
Chinese Journal of Ophthalmology
关键词
结膜肿瘤
黏液瘤
血管黏液瘤
病理学
临床
Conjunctival neoplasms
Myxoma
Angiomyxoma
Pathology,clinical
