摘要
目的 研究血清细胞间粘附分子 1(sICAM 1)在肝细胞肝癌 (HCC)复发前后的变化 ,探讨其在复发监测中的价值。方法 应用酶联免疫分析测定 41例HCC术后复发患者sICAM 1水平 ,并与血清甲种胎儿球蛋白 (AFP)进行同步分析。结果 确诊肝癌复发时 ,所有患者sICAM 1水平均较复发前升高 ,其均值为 (12 89± 317) μg/L。其中 73.2 %的患者sICAM 1>10 0 0 μg/L ,而血清AFP阳性者仅占 6 0 .0 % ,6例AFP阴性复发者sICAM 1较复发前升高 2～ 4倍 ,持续 1～ 4个月后 ,影像学检查才发现肝占位性病变。结论 HCC术后血清sICAM 1水平变化对预测肿瘤复发有一定的临床价值 ,尤其对AFP阴性的患者。
Objective\ To evaluate the clinical value of serum intercellular adhesion molecule 1 (sICAM 1) in monitoring postoperative recurrence of hepatocellular carcinoma (HCC).Methods\ Serum levels of sICAM 1 were measured by using ELISA in 41 patients with recurrence of HCC, which were compared with those of serum α fetoprotein (AFP) in the same patients. Results\ The levels of sICAM 1 were significantly increased in all patients when tumor recurrence was diagnosed. The levels of sICAM 1 were higher than 1 000 μg/L in 73.2% of the patients. The rate, however, of the patients with positive for AFP was only 60%, In 6 patients with AFP negative, tumor recurrence was not detected by liver image until their serum levels of sICAM 1 had exceeded 2～4 times higher than before for 1～4 months. Conclusion\ Observation of changes of sICAM 1 levels in HCC patients undergoing hepatectomy is of clinical value of predicting tumor recurrence during postoperative follow up, particularly for those pataents with AFP negative.
出处
《中华实验外科杂志》
CSCD
北大核心
2000年第2期141-142,共2页
Chinese Journal of Experimental Surgery
基金
:广西青年科学基金! ( 98110 0 3 )
关键词
复发
原发性肝细胞癌
SICAM-1
血清诊断
Carcinoma
hepatocellular
\ Recurrence
\ Serum intercellular adhesion molecule 1
