摘要
目的 :比较临床常用液体用于创伤失血性休克液体复苏后肺组织损伤程度的影响 ,为创伤失血性休克实施理想的液体复苏治疗提供依据。方法 :比较急性失血大鼠以不同液体复苏后血清细胞因子水平、肺通透性指数变化及肺组织形态学改变。结果 :L R组血清 TNFα,IL- 6水平高于其它各组 ,病理检查肺泡腔渗出液最明显 ,胶体复苏组 BAL F中蛋白含量明显高于晶体组。结论 :急性失血以不同液体复苏后早期即出现程度不同的肺损伤 ;TNFα及 IL - 6是介导此损伤的重要介质 ;
Objective:To test the hypothesis that different resuscitative fluids may immediately affect the degree of acute lung injury following hemorrhage, and to provide the scientific basis for the perfect fluid treatment in hemorrhage. Methods:Comparing the cytokine concentration in plasmas, lung permeability index and morphologic appearance of SD rats with different fluids after hemorrhage and resuscitation. Results:Resuscitation with LR solution resulted in a significant elevation of TNFα and IL 6 level in plasma and significant morphologic appearance. Concentration of protein in BAL fluid was more significantly increased in the groups resuscitated with colloid than in LR group. Conclusion:1. Different resuscitative fluids resulted in different degrees of acute lung injury after hemorrhage. TNFα and IL 6 were the chief cytokines mediating the early lung injury. 2. Significant hemodilution was observed in colloid groups and it beneficially influenced the lung injury, but resuscitation with colloid increased the egress of protein, and this adversely influenced the lung injury.
出处
《军医进修学院学报》
CAS
2000年第1期20-22,共3页
Academic Journal of Pla Postgraduate Medical School
基金
"九五"军队科研基金!项目( 96 L 0 5 3
