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MGMT表达与替莫唑胺治疗多形性胶质母细胞瘤耐药的关系 被引量:4

O^6-Methylguanine DNA methyltransferase protein expression and TMZ resistance in patients with glio. blastoma multiforme
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摘要 多形性胶质母细胞瘤是中枢神经系统最常见的恶性肿瘤,而且在胶质瘤中恶性程度最高。替莫唑胺为治疗多形性胶质母细胞瘤的新型烷化剂类口服化疗药物,研究表明替莫唑胺的耐药机制与O6-甲基鸟嘌呤.DNA甲基转移酶(MGMT)的表达相关。了解多形性胶质母细胞瘤应用替莫唑胺治疗的耐药性与MGMT表达的相关性对临床治疗很有帮助。 Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central nervous system and the most malignant tumor among gliomas. Temozolomide is a newly alkylating oral drug on the treatment of glioblastoma multiforme. Some studies indicated that protein expression of 06-methylguanine-DNA-methyhransferase (MGMT) is the most important determinant of TMZ resistance. Here, the relationship of MGMT expression with TMZ resistance in glioblastoma muhiforme patients will be reviewed.
出处 《国际免疫学杂志》 CAS 2012年第6期453-456,共4页 International Journal of Immunology
关键词 多形性胶质母细胞瘤 替莫唑胺 MGMT Glioblastoma muhiforme Temozolomide O^6-methylgu-anine-DNA-methyltransferase
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