摘要
目的:观察康艾注射液联合FLO化疗方案治疗晚期胃癌的临床疗效。方法:将符合入选标准的80例晚期胃癌患者随机分为观察组、对照组各40例。两组均采用FLO方案:5-氟脲嘧啶2 600 mg·m-2+500 mL生理盐水静脉滴注,d1～8;亚叶酸钙200 mg·m-2+500 mL生理盐水静脉滴注,d1-8;奥沙利铂85 mg·m-2+500 mL生理盐水静脉滴注,d1-8。观察组同时给予康艾注射液40 mL·d-1静脉滴注,d1～14,3周为1个周期,最少连续治疗2个周期后评价临床疗效、不良反应及生存质量改善情况。结果:总有效率观察组为57.50%,对照组为25.00%,两组差异显著(P<0.05)。两组均出现了白细胞减少、血小板减少、贫血、恶心呕吐、肝功能异常、肾功能异常、周围神经毒性、脱发等毒副反应,但对照组毒副反应反应率较观察组高(P<0.05)。观察组生存质量改善较对照组明显(P<0.05),其中KPS评分上升率观察组为70%,对照组为37.5%;下降率观察组为5.0%,对照组为22.5%。两组KPS评分上升率、下降率相比差异有统计学意义。结论:康艾注射液联合FLO化疗方案治疗晚期胃癌临床疗效好,毒副反应小,改善生存质量的程度较好。
Objective： To observe clinical curative effect of Kang＇ai injection combined with FLO chemotherapy regimen for advanced gastric cancer. Method： According to case inclusion criteria, 80 patients with advanced gastric cancer were randomly divided into observation group and control group, 40 cases in each. Two groups were treated with FLO regimen： 5-fluorouracil 2 600 mg.m-2 ＋ 500 mL intravenous saline infusion, d1-8; calcium folinate 200 mg.m-2 ＋ 500 mL intravenous saline infusion, d1-8; oxaliplatin 85 mg.m-2 ＋ 500 mL intravenous saline infusion, d1-8. The observation group was given Kang＇ai injection intravenous infusion of 40 mL.d-1, d1-14, every 3 weeks for a cycle, 2 consecutive cycles at least, then followed with the evaluation of the clinical efficacy, adverse reactions and living quality. Result： The total effective rate was 57.50% in the observation group, 25% in control group, and the two groups showed significant difference （P 〈 0. 05）. The two groups showed neutropenia, thrombocytopenia, anemia, nausea and vomiting, abnormal liver function, renal function abnormalities, peripheral neurotoxicity, hair loss and other side effects, but the control group toxicity reaction rate was higher than that in the observation group, with significant difference statistically （P 〈 0. 05）. The quality of life in observation group was improved significantly compared with that in the control group （P 〈 0.05 ） , the increasing rate of karmovsky performance statas（KPS） score was 70% in the observation group, while 37.5% in control group; the declining rate of KPS score was 5% in the observation group, while 22. 5% in the control group. These changes in KPS score in the two groups were statistically significant. Conclusion： Kang＇ ai injection combined with FLO chemotherapy in treatment of advanced gastric cancer shows good clinical curative effect, less side effects, and improved quality of life.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第22期325-327,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
胃癌
晚期
化疗
FLO
康艾注射液
gastric cancer
late stage
chemotherapy
FLO regimen
Kang＇ai injection
