摘要
乳腺癌是女性常见恶性肿瘤,骨转移发生率约为65%~75%。一旦发生骨转移,将伴有病理性骨折、脊髓压迫、高钙血症、剧烈疼痛等,严重影响患者生存质量。近来研究发现维生素D不仅能降低乳腺癌患病率、复发率和死亡率,还可降低乳腺癌骨转移的发生率。现将相关研究作如下综述。
出处
《实用医学杂志》
CAS
北大核心
2012年第21期3666-3668,共3页
The Journal of Practical Medicine
参考文献20
-
1Peppone L J, Huston A J, Reid M E, et al. The effect of various vitamin D supplementation regimens in breast cancer patients [J]. Breast Cancer Res Treat, 2011,127 (1) : 171-177. 被引量:1
-
2Bortman P, Folgueira M A, Katayama M L, et al. Antiproliferative effects of 1,25-dihydroxyvitamin D3 on breast cells: a minireview [J]. Braz J Med Bio Res, 2002,35 ( 1 ) : 1-9. 被引量:1
-
3Chakraborti C K. Vitamin D as a promising anticancer agent [J]. Indian J Pharmacol, 2011,43(2) : 113-120. 被引量:1
-
4Morrison M A, Silveira A C, Huynh N, et al. Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age- related macular degeneration [J]. Hum Genomics, 2011,5 (6) : 538-568. 被引量:1
-
5Crew K D, Shane E, Cremers S, et al. High prevalence of vitamin D deficiency despite supplementation in premeno- pausal women with breast cancer undergoing adjuvant chemotherapy [J]. J Clin Oneol, 2009,27 (13):2151- 2156. 被引量:1
-
6Vashi P G, Trukova K, Lammersfeld C A, et al. Impact of oral vitamin D supplementation on serum 25 - hydroxyvitamin D levels in oncology [J]. Nutr J, 2010,9:60. 被引量:1
-
7Trukova K P, Grutsch J, Lammersfeld C, et al. Prevalence of vitamin D insufficiency among breast cancer survivors [J]. Nutr Clin Pract, 2012, 27( 1 ) : 122-128. 被引量:1
-
8Lopes N, Carvalho J, Duries C, et al. 1Alpha, 25-dihydroxyvitamin D3 induces de novo E-cadherin expressionin triple-negative breast cancer cells by CDHl-promoter demethylation [J]. Anticancer Res, 2012,32 (1):249- 257. 被引量:1
-
9刘静,赵浩亮.1,25二羟维生素D_3与三苯氧胺对乳腺癌细胞生长及凋亡的影响[J].中国药物与临床,2007,7(7):534-535. 被引量:3
-
10Sergeev I N. Vitamin D and cellular Ca2+ signaling in breast cancer [J]. Anticancer Res, 2012,32 (1):299- 302. 被引量:1
二级参考文献4
-
1Ercoli A,Scambia G.Comparative study on the indication of eytostasis and apoptosis by ICI182780 and tamoxifen in an estrogen receptor-negative ovarian cancer cell line.Int J Cancer,1998,76:47-54. 被引量:1
-
2Barbareschi M,Veronese S,Caffo O,et al.bcl-2 and p53 expression in node-negative breast carcinoma:a study with long term follow-up.Hum Pathol,1996,27:1149-1155. 被引量:1
-
3Issa LL Leong GM,Eisman JA.Molecular mechanism of vitamin D receptor action.Adv Exp Med Biol,1996,399:53-70. 被引量:1
-
4Wang TIY.Phang JM.Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7.Cancer Res,1995,55:2487-2489. 被引量:1
同被引文献51
-
1KARANIKOLAS B D,FIGUEIREDO M L,WU L.Polycomb group protein enhancer of zeste2is an oncogene that promotes the neo-plastic transformation of a benign prostatic epithelial cell line[J].Mol Cancer Res,2009,7:1456-1465. 被引量:1
-
2BREUER R H,SNIJDERS P J,SMIT E F,et al.Increased expres-sion of the EZH2polycomb group gene in BMI-l-positive neo-plastic cells during bronchial carcinogenesis[J].Neoplasia,2004,6(6):736-743. 被引量:1
-
3WEIKERT S,CHRISTOPH F,KOLLERMANN J,et al.Expression levels of the EZH2polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas[J].Int J Mol Med,2005,16(2):349-353. 被引量:1
-
4ARISAN S,BUYUKTUNCER E D,PALAVAN-UNSAL N,et al.Increased expression of EZH2,a polycomb group protein,in blad-der carcinoma[J].Urol Int,2005,75(3):252-257. 被引量:1
-
5CARDOSO C,MIGNON C,HETET G,et al.The human EZH2 gene:genomic organization and revised mapping in7q35within the critical region for malignant myeloid disorders[J].Eur J Hum Genet,2000,8(3):174-180. 被引量:1
-
6KLEER C G,CAO Q,VARAMBALLY S,et al.EZH2is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells[J].Proc Natl Acad Sci USA,2003,100(20):11606-11611. 被引量:1
-
7RAAPHORST F M,MEIJER C J,FIERET E,et al.Poorly differen-tiated breast carcinoma is associated with increased expression of human polycomb group EZH2gene[J].Neoplasia,2003,5(6):481-488. 被引量:1
-
8VARAMBALLY S,DHANASEKARAN S M,ZHOU M,et al.The polycomb grop protein EZH2is involved inprogression of prostate cancer[J].Nature,2002,419(6907):624-629. 被引量:1
-
9ZETTER B R,BANYARD J CANCER.The silence of the genes[J].Nature,2002,419(6907):572-573. 被引量:1
-
10SUDO T,UTSUNOMIYA T,MIMORI K,et al.Clinicopathological significance of EZH2mRNA expression in patients with hepatocel-lular carcinoma[J].Br J Cancer,2005,92(9):1754-1758. 被引量:1
引证文献5
-
1胡赟宏,林晓燕,崔嵘嵘,王铮元,许诚.EZH2蛋白在乳腺癌中的表达及其临床意义[J].现代医院,2013,13(7):63-64. 被引量:6
-
2赵秋剑,高海锋,王利公,李有怀.乳腺癌中钙敏感受体、维生素D、钙浓度的表达水平及相关性研究[J].医学综述,2016,22(12):2401-2403. 被引量:4
-
3武四美,文兆明,俞根.血清中维生素D、血钙的水平与乳腺癌的关系研究[J].江西医药,2017,52(4):323-325. 被引量:3
-
4孙宁宁,明洁,丁燕美,梁惠.三阴性乳癌病人血清矿物质及脂质水平的检测[J].齐鲁医学杂志,2017,32(4):456-458.
-
5赵海燕,苏乌云,云升.维生素D与乳腺癌骨转移的关系[J].世界最新医学信息文摘,2016,0(31):87-87. 被引量:2
二级引证文献15
-
1廖洪利,许爱敏.Dkk1表达和乳腺癌细胞侵袭转移的关系[J].实用医学杂志,2014,30(3):371-373.
-
2况丽平,王媛媛,管慧红,郑晓璇,沈金辉,王少洪.TopoⅡa和Ki-67在不同分子亚型乳腺癌组织中的表达及意义[J].实用医学杂志,2014,30(5):778-780. 被引量:6
-
3王明虹.NT-proBNP与CVP对蒽环类药物致心脏毒性的早期监测应用的临床意义[J].现代肿瘤医学,2014,22(9):2182-2183. 被引量:2
-
4熊超,曾灵芝,廖立潇.TAFI在乳腺癌患者中的水平变化及临床意义[J].江西医药,2017,52(7):620-622.
-
5卢玉元,王新.联合检测Annexin A3和EZH2蛋白在乳腺癌组织中的表达及临床意义[J].沈阳医学院学报,2017,19(4):310-312.
-
6孙宁宁,明洁,丁燕美,梁惠.三阴性乳癌病人血清矿物质及脂质水平的检测[J].齐鲁医学杂志,2017,32(4):456-458.
-
7于洋,梁栋,吕峰,杨秦蘅,申鹏,张斌,张文忠,尤伟.Ki-67、miR-182在乳腺浸润性导管癌中的表达及相关性[J].中国现代普通外科进展,2017,20(10):807-810. 被引量:2
-
8韦学昌,刘晓锋,叶青,刘频.肺癌伴脊柱转移癌的外科治疗疗效分析[J].中华骨与关节外科杂志,2018,11(10):772-775. 被引量:3
-
9霍记平,杨树,梅升辉,赵志刚,田晶辰.维生素D与乳腺癌发生风险的相关性研究进展[J].药品评价,2018,15(24):10-14. 被引量:1
-
10吴丽然.经乳晕切口手术用于乳腺纤维瘤治疗的效果[J].中国卫生标准管理,2019,10(1):57-59. 被引量:4
-
1赵海燕,苏乌云,云升.维生素D与乳腺癌骨转移的关系[J].世界最新医学信息文摘,2016,0(31):87-87. 被引量:2
-
2米丰年,殷德厚,刘长林.维生素D在治疗急性白血病中的应用[J].山西白血病,1993,2(2):93-94.
-
3李宗正,孙涛,宋军.脊髓肿瘤100例临床分析[J].江苏医药,2004,30(5):336-336. 被引量:1
-
4金捷,曾凌华,易玉珍.维生素D与视网膜母细胞瘤[J].国外医学(眼科学分册),1989,13(2):72-78.
-
5库建伟.唑来膦酸治疗恶性肿瘤骨转移58例疗效观察[J].山东医药,2007,47(16):82-83.
-
6郭英辉,张啸,钱礼.恶性肿瘤与高钙血症[J].国外医学(内科学分册),1993,20(12):540-543.
-
7池肇春.原发性肝癌致高钙血症五例报告[J].临床肝胆病杂志,1992,8(3):154-155. 被引量:2
-
8桂保松,朱建民.恶性肿瘤伴发高钙血症的发病机理及处理[J].中华内科杂志,1994,33(11):736-738. 被引量:1
-
9柳勋法,张更伟,钟贤良.伊班膦酸钠在恶性肿瘤骨转移临床治疗中的应用效果分析[J].中国医药导刊,2013,15(12):2020-2021. 被引量:1
-
10韦秀英,黄平,庞媛尹.恶性肿瘤伴发高钙血症18例临床分析[J].广西医学,2005,27(3):397-397. 被引量:2