摘要
目的:探讨卡介菌多糖核酸对面部局限型白癜风的疗效及其对外周血T淋巴细胞亚群的影响。方法:100例面部局限型白癜风患者随机分为两组,治疗组50例用卡介菌多糖核酸治疗,对照组50例常规疗法治疗;两组均治疗3个月;治疗组中38例患者治疗前后用流式细胞仪检测外周血T淋巴细胞亚群,与20例健康体检者做对照。结果:治疗组的总有效率为58.0%,明显高于对照组25.0%(P<0.05),治疗前治疗组与体检组比较CD4、CD4/CD8降低(P<0.05),CD3、CD8变化不明显(P>0.05)。治疗组经卡介菌多糖核酸治疗后CD4、CD4/CD8明显升高(P<0.05)。卡介菌多糖核酸对稳定期、病程≤1年的患者疗效好于进展期、病程>1年的患者。稳定期,病程≤1年的患者2个月后的复发率明显低于进展期,病程>1年的患者。结论:白癜风患者存在细胞免疫功能异常;卡介菌多糖核酸能提高患者细胞免疫功能,用于治疗面部局限型白癜风安全有效。
Objective To observe the effection of BCG-PSN on patients with facial limited type vitiligo and T-lymphocyte sub- population in peripheral blood. Methods 100 patients who with facial limited type vitiligo were randomly divided into the treatment group （50 patients were treated with BCG-PSN） and the control group （50 patients were treated with routine treatment ）.These two groups had been treated for 3 months.38 patients of the treatment group were detectived T-lymphocyte sub-population by flow cytometric before and after treatment.And 20 healthy persons were as a comparison. Results Effective rate of treatment group and control group was 58% and 25% respectively.（P〈0.05）Before the treatment,the number of CD4,CD4/CD8 of the patients was lower than that of healthy control （P〈0.05）while CD3,CD8 did not change significantly.After the treat with BCG-PSN,CD4,CD4/CD8 of the patients increased significantly （P〈0.05）.lt was better curative effect for the patients who were in stable period or whose courses of disease were ≤ 1 year than the patients who were in advanced period or whose courses of disease were〉l year after be treated by BCG-PSN. The two months later recurrence rate of the patients who were in stable period or whose courses of the disease were≤ 1 year was significantly less than the patients who were in advanced period or whose courses of the disease were〉l year. Conclusion These results reveal that cellular immunity is impaired in vitiligo patients.BCG-PSN can enhance cellular immunity of the patients.And it is a safe and effective way to treat the facial limited type vitiligo.
出处
《中国美容医学》
CAS
2012年第08X期107-108,共2页
Chinese Journal of Aesthetic Medicine
