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热休克蛋白65促动脉粥样硬化发生及进展的机制 被引量：1

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摘要 多年来，一直认为动脉粥样硬化（atherosclerosis，AS）是一种脂质沉积病。但是，近年人们对AS的发病机制有了新的认识，认为炎性免疫反应在AS发展阶段中起着关键的作用。一些学者已经把AS定义为慢性炎症与自身免疫反应交互的过程。许多证据表明，由于热休克蛋白（HSP）在各不同物种间的高度保守序列及交叉反应，可激活自身免疫反应，促进细胞因子的分泌，在AS形成中具有重要作用。
作者 孙海阁 刘挺榕 谭迎 郭志刚
机构地区 南方医科大学南方医院心内科
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2012年第11期1221-1223,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 广东省科技计划项目(2011B031800065)
关键词 热休克蛋白质类 动脉粥样硬化 T淋巴细胞 白细胞介素12 干扰素Ⅱ型
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

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二级参考文献15

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共引文献3

同被引文献12

  • 1Khera AV,Cuchel M, de la l.lera Moya M, et al. Cholesterol efflux capacity,high density lipoprotein function, and athero sclerosis. N Engl J Med,2011,364:127-135. 被引量：1
  • 2Zhang, Y, Xiong Q, Hu X, et al. A novel atherogenic epitope from mycohacterium tuberculosis heat shock protein 65 en hances atherosclerosis in rabbit and LI)I. receptor defieiem mice. Heart Vessels, 2012,27 : 411 -418. 被引量：1
  • 3Jun L,Jie L,Xin Y,et aL Nasal immunization with different forms of heat shock proleim65 reduced high cholesterol diet driven rabbit atherosclerosis. International Immunopharma cology,2012,13:82- 87. 被引量：1
  • 4Zhao SP,Yang J,Li J,et al. Effect of niacin on l.XRalpha and PPARgamma expression and HDL induced cholesterol efflux in adipocytes of hypereholesterol rabbits. Int J Cardiol,2008, 124:172 -178. 被引量：1
  • 5Carolina P, Fernanda P,Eliana M,et al. Autolytic mycobacte rium leprae hsp65 fragments may act as bio[ogical markers for autoimmune diseases. Microbial Pathogenesis, 2011,51 : 268- 276. 被引量：1
  • 6Wu J,Ma H,Qu Q,et al. Incorporation of immunostimulatory motifs in the transcribed region of a plasmid DNA vaccine en hances Thl immune responses and therapeutic effect against mycobacterium tuberculosis in mice. Vaccine, 2011,29 : 7624- 7630. 被引量：1
  • 7Zhong JK,Guo ZG,I.i C,et al. Probucol alleviates atheroscle rosis and improves high density lipoprotein funclion. I.ipids Health Dis,2011,10:210 -219. 被引量：1
  • 8Azzam KM, Fessler MB. Crosstalk between reverse cholester ol transport and innate immunity. Trends Endocrinol Metab, 2012,23:169-178. 被引量：1
  • 9Yvan-Charvet L,Wang N, Tall AR. Role of HDI., ABCA1. and ABCG1 transporters in cholesterol efflux and immune re sponses. Arterioscler Thromb Vasc P, iol. 2010,30 : 139 -143. 被引量：1
  • 10Huang CX, Zhang YI.. The target of regulating the ATP binding cassette AI protein (ABCAI) : promoting ABCAI mediated cholesterol efflux in different cells. Curt Pharm Bio technol,2013,14:623631. 被引量：1

引证文献1

中华老年心脑血管病杂志
2012年 第11期

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