摘要
子宫内膜异位症(EMs)是一种雌激素依赖性疾病,局部雌激素的大量形成在EMs的发生与发展中发挥重要的作用。芳香化酶是雌激素合成过程中的关键酶。近年来研究已经证实,EMs患者的在位和异位内膜均有芳香化酶的异常高表达,而正常子宫内膜却无该酶的表达,且已有不少芳香化酶抑制剂治疗EMs成功的病例报道。然而最近的研究发现,类固醇合成因子1(SF-1)在正常子宫内膜基质细胞中不表达,而在异位内膜基质细胞中异常表达,SF-1是异位子宫内膜组织芳香化酶合成的主要调控者,EMs患者的异位和在位内膜中芳香化酶表达量直接受SF-1表达的影响,而SF-1表达的异常主要是由于表达该蛋白的基因启动子区的过甲基化。综述SF-1在EMs发病机制中作用的研究进展。
Endometriosis is an estrogen-dependent disease.Local estrogen biosynthesis is a major factor in the pathogenesis of endometriosis.Aromatase is a key enzyme during the process of estrogen biosynthesis.Recent studies have demonstrated that aromatase both in eutopic and ectopic endometrium of patients with endometriosis expressed highly,but didn′t express in the normal endometrium,and there were several successful treatment cases of endometriosis with aromatase inhibitors.However,recent studies have found that steroidogenic factor 1（SF-1） didn′t express in normal endometrial stromal cells,but highly expressed in ectopic stromal cells.SF-1 plays an important role in the synthesis of aromatase.The level of SF-1 directly affected the expression of aromatase,while the abnormal expression of SF-1 mainly due to the hypermethylation of SF-1 gene promoter region.In this paper,we make a review about the role of SF-1 playing in the pathogenesis of endometriosis.
出处
《国际妇产科学杂志》
CAS
2012年第5期499-502,共4页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(NSFC81070468)
