摘要
目的探讨高通量血液净化联合百令胶囊对慢性肾功能衰竭的治疗效果及其对微炎症的影响。方法将63例慢性肾功能衰竭患者随机分为A组、B组与C组,A组采用低通量血液净化治疗,B组采用高通量血液净化治疗,C组采用高通量血液净化联合百令胶囊治疗,观察并比较三组患者的临床疗效以及血肌酐、尿素氮、24 h尿蛋白、β2-微球蛋白、血清白蛋白等生化指标,以及白介素-6、肿瘤坏死因子-α以及高敏C反应蛋白等微炎症指标。结果B组及C组治疗总有效率均为95.24%,显著高于A组的90.48%(P<0.05);与治疗前相比,A组仅肌酐与尿素氮显著降低,B组及C组患者血肌酐、尿素氮、24 h尿蛋白、β2-微球蛋白水平均显著降低,以C组更为显著(P<0.05);治疗前后所有患者血清白蛋白变化不明显(P>0.05);B组及C组患者治疗后血清白介素-6、肿瘤坏死因子-α以及高敏C反应蛋白显著降低,以C组降低更为明显(P<0.05)。结论高通量血液净化联合百令胶囊治疗肾功能衰竭效果肯定,对微炎症状态控制良好,优于单用高通量血液净化或低通量血液净化。
Objective To explore clinical effects of combination therapy of HFHD and Bailing Capsules in the treatment of chronic renal failure（CRF）.Methods 63 patients with CHF were divided into group A,B and C.Group A was given treatment of LFHD,group B was given treatment of HFHD,while group C was given combined therapy of HFHD and Bailing Capsules.The clinical efficacy was observed and compared among the three groups;biochemical parameters such as Scr,BUN,24 h urinary albumen,β2-MG and serum albumen were compared;inflammatory factors such as IL-6,TNF-α and hs-CRP were compared.Results Treatment efficacy of group B（95.24%） and group C（95.24%） were found significantly higher than group A（90.48%）（P 0.05）;Scr and BUN were found decreased significantly in group A;Scr,BUN,24 h urinary albumen,β2-MG were found decreased significantly after treatment for patients in group B and C,more significantly in group C（P 0.05）;no significant differences of serum albumen were found before and after treatments and between two groups（P 0.05）;serum levels of IL-6,TNF-α and hs-CRP were found decreased significantly in group B and C,more significantly in group C（P 0.05）.Conclusion Combined therapy of HFHD and Bailing Capsules shows confirmed clinical effects to CRF,controlling inflammation efficiently,better than application of HFHD or LFHD along.
出处
《中国医药导报》
CAS
2012年第30期84-85,88,共3页
China Medical Herald
