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参麦注射液治疗急性非ST段抬高型心肌梗死及对组织因子途径抑制物-2的影响 被引量:2

The Efficacy of Shenmai injection on non-ST elevation myocardial infarction and its effect on tissue factor pathway inhibitor-2
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摘要 目的探讨参麦注射液对急性非ST段抬高型心肌梗死治疗疗效并了解其机制。方法选非ST段抬高型心肌梗死患者170例随机分观察组及对照组各85例,对照组常规西药治疗,观察组在对照组的基础上应用参麦注射液。观察临床症状及心电图缓解情况,并检测治疗前后患者血浆组织因子途径抑制物2的浓度。结果临床治疗效果观察组总有效率90.59%,心电图改善总有效率91.67%高于对照组的76.47%、77.64%。两组治疗前组织因子途径抑制物-2水平无显著性差异(P>0.05);治疗以后观察组(7.79±1.112)ng/mL低于对照组的(8.86±1.29)ng/mL,差值为(2.24±0.78)ng/mL高于对照组的(1.14±0.60)ng/mL(P<0.05)。结论参麦注射液可有效提高急性非ST段抬高型心肌梗死治疗效果及心电图改善,参麦注射液对急性非ST段抬高心肌梗死的治疗作用可能与组织因子途径抑制物-2水平变化相关。 Objective To study clinical effects of Shenmai injection on non-ST elevation myocardial infarction(NSTEMI) and understand its mechanism. Methods All of 170 cases with NSTEMI were divided into treatment group (85 cases) and control group (85 cases). Treatment group was conventional western medicine plus Shenmai injection. Otherwise, the control group was conventional western medicine. Observed symptoms and ECG remission.situation and detected the plasmatissue factor pathway inhibitor-2(PTFI-2) concentration before and after treatment. Results In treatment group, total effective rate of clinical treatment effect was 90.59%, the total efficiency rate of ECG improvement was 91.67%. It's higher than 76.47%, 77.64% in control group. There were no significant differences of PTFI-2 before treatment between the two groups (P 〉 0.05). After treatment, the PTFI-2 level in treatment group (7.79±1.112 ng/mL) was lower than that in the control group (8.86±1.29) ng/mL) in the observation group, the difference of PTFI-2 before and after treatment (2.24±0.78)ng/mL was higher than that in control group (1.14±0.60 ng/mL)(P 〈 0.05). Conclusion The Shenmai injection plus the conventional western medicine can effectively alleviate the NSTEMI. It's treatment effect may be related to the changes of tissue factor pathway inhibitor-2.
出处 《中国现代医生》 2012年第26期58-60,共3页 China Modern Doctor
基金 浙江省医学会"临床科研基金"项目(2010ZYC-A19)
关键词 参麦注射液 急性非ST段抬高型心肌梗死 组织因子途径抑制物-2 Shenmai iinjection non-ST elevation myocardial infarction Tissue factor pathway inhibitor-2
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