摘要
目的观察静脉注射三乙醇胺后SD大鼠的组织病理学改变及其可逆性。方法 60只SD大鼠,随机分为对照组和300mg/kg剂量组,连续30d给药和恢复4周,分别进行大体解剖和组织病理学检查。结果连续给药30d,SD大鼠肝细胞嗜酸性变,肾髓质肾小管上皮细胞变性,脾小体生发中心增大,白髓边缘带增宽,淋巴结内淋巴滤泡数量增多,生发中心增大;恢复4周,肝脏、脾脏和淋巴结病变恢复不明显。结论静脉注射一定剂量的三乙醇胺,对SD大鼠肝脏、肾脏、脾脏和淋巴结有一定的损伤作用,其中,肾脏的损伤可逆,脾脏、淋巴结和肝脏的损伤有一定程度的恢复。
Objective To observe the histopathological change of SD rats after iv administration with trolamine and its recoverability.Methods Sixty rats were divided into control group and rolamine group（300 mg/kg）,and gross anatomy and histopathology observation were carried out after the continuous administration for 30 d and the recovery for four weeks.Results Some tissue structures of SD rats via 30 d successive administration,such as liver,kidney,spleen,and lymph node,were changed,such as hepatocyte acidophily change,part epithelial cell degeneration of renal tubule in the renal medulla,the increase of the number of lymphoid follicle and the volume of germinal center in lymph node,and the volume of germinal center and the boundary zone of white pulp in spleen.The reversablity of these changes except kidney is not obvious.Conclusion The liver,spleen,kidney,and lymph nod are injuried by trolamine via iv injection.The damage of kidney is reversible,but the damage of the liver,spleen and lymph nod could only be reversed partly.
出处
《药物评价研究》
CAS
2012年第5期351-353,共3页
Drug Evaluation Research
