摘要
目的观察天保宁片对原发性高血压患者(EH)血小板活化因子、VWF和血小板聚集率的影响,探讨其对心脑血管并发症的预防作用。方法检测27例健康对照者和61例原发性高血压患者血小板活化因子(PAF)、血管性血友病因子(VWF)和血小板聚集率(PAR)水平,并将患者随机分为单纯降压治疗组(对照组,27例)和合并天保宁治疗组(治疗组,n=34例),分别于治疗前和治疗后20天测定PAF、VWF和PAR水平。结果高血压组PAF、VWF和PAR分别为7.14±1.46ng/ml、(145.6±26.2)%和(84.2±9.9)%,均高于正常对照组的2.23±0.67ng/ml、(97.3±18.2)%和(48.6±8.4)%,差异均有统计学意义(P<0.001)。天保宁组治疗后PAF、VWF和PAR分别为4.33±0.89ng/ml、(103.5±23.5)%和(55.±13.6)%,均低于治疗前的7.21±1.46ng/ml、(142.5±29.5)%和(86.3±15.9)%,差异均有统计学意义(P<0.001),对照组治疗后PAF、VWF和PAR水平分别为6.55±1.30ng/ml、(138.2±28.9)%和(76.5±17.1)%,与治疗前的7.06±1.38ng/ml、(149.3±31.2)%和(81.7±18.9)%差异均无统计学意义(P>0.05)。结论天保宁可明显降低原发性高血压患者PAF、VWF和PAR水平,对心脑血管并发症具有预防作用。
Objective To observe the effects of Tianbaoning tablet on platelet activation factor （PAF） , von Willebrand factor （VWF） and platelet aggregation rate（PAR） in patients with essential hypertension, and to explore its prevention effects on cardiocerebral vascular complications. Methods The levels of PAF, VWF and PAR were measured in 27 healthy controls and 61 patients with essential hypertension（EH）. The patients with EH were randomly divided into blood pressure -lowering treatment group （control group） and Tian- baoning -combinating treatment group（ Tianbaoning group）. Before treatment and after 20 days of treatment, the levels of PAF, VWF and PAR were measured, respectively. Results At EH group, the levels of PAF, VWF and PAR were remarkably higher than those at healthy control group （P 〈 0. 001 ）. At Tianbaoning group, the levels of PAF,VWF and PAR after 20 days of treatment were significantly lower than those before treatment （P 〈 0. 001 ）. But at control group, the levels of the four indicators showed less difference between after 20 days of treatment and before treatment（P 〉 0.05）. Conclusion Tianbaoning can prevent patients from cardiocerebral vascular com- plications mainly via reducing the levels of platelet activation factor, yon Willebrand factor and platelet aggregation rate in patients with es- sential hypertension.
出处
《医学研究杂志》
2012年第10期158-160,共3页
Journal of Medical Research
关键词
天保宁
原发性高血压
血小板活化因子
VWF
血小板聚集率
Tianbaoning
Essential hypertension
Platelet activation factor
yon Willebrand factor
Platelet aggregation rate
