摘要
全身性感染是重症医学科的常见病及多发病,一旦合并脏器功能不全,病死率非常高。早期合理的治疗可以明显降低全身性感染患者的预后,然而,由于缺乏特异性的临床症状及体征,使得全身性感染的早期诊断十分困难。机体发生感染后,生物标记物往往在临床症状体征出现之前就发生改变,有助于全身性感染的诊断。然而,单一的生物标记物的诊断价值均较有限。动态观察生物标记物的变化以及联合多种生物标记物则有助于提高生物标记物的诊断价值。临床医生必须熟悉各种生物标记物的特点,才能做出准确的诊断。本文主要针对生物标记物在全身性感染中的诊断价值进行阐述。
Sepsis is a major cause of morbidity in intensive care unit （ ICU）, and the mortality is very high when it induces or- gan dysfunction. Appropriate initial treatment could improve the outcome of sepsis. However, it is very difficult to diagnose because of the lack of specific clinic symptom and sign. When severe sepsis occurs, biomarkers could be helpful for diagnosis. Unfortunately, the di- agnostic value of single biomarker is limited. Dynamic changes of a biomarker or combination of several biomarkers could enhance the diagnostic value. Therefore, clinicians should know the characteristics of biomarkers. The diagnostic value of biomarkers in sepsis is re- viewed in this paper.
出处
《实用医院临床杂志》
2012年第6期27-30,共4页
Practical Journal of Clinical Medicine
基金
卫生公益性行业科研专项经费项目(编号:201202011)
江苏省"科教兴卫工程"医学重点学科项目(编号:889-KJXW11.3)
