摘要
目的本实验通过检测HIV感染者NKT样细胞基线功能的变化,研究NKT样细胞对HIV感染疾病进程的影响。方法应用流式细胞术直接对HIV感染者以及健康对照外周血NKT样细胞IFN-γ分泌和CD107a表达进行研究。结果 NKT样细胞分泌IFN-γ百分比高者HIV疾病进展慢(P<0.008,P<0.001),与CD4+T细胞计数呈显著正相关(r=0.402,P=0.027),而与病毒载量呈显著负相关(r=-0.472,P=0.037)。结论 NKT样细胞功能较强,具有免疫保护作用,是延缓HIV病程的重要因素之一,可作为监测HIV疾病进展的指标。
To better understand the baseline function of the NKT like cells in HIV infected individuals,we collected peripheral blood from HIV infected individuals and healthy controls,and analyzed interferon-γ（IFN-γ） frequency and CD107a expression of natural killer T like cells by flow cytometry.We found that the individuals with high IFN-γ secretion in NKT like cells has slower disease progression（P 〈 0.008,P 〈 0.001）.IFN-γ production of NKT like cells correlated inversely with viral loads（r=-0.472 and P=0.037）,and positively with CD4＋ T cells counts（r=0.402 and P=0.027）.In conclusion,IFN-γ production by NKT like cells in HIV patients might be one of the multiple factors against HIV infection,and is an indicator for HIV infection progression.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2012年第11期954-958,共5页
Immunological Journal
基金
国家科技重大专项课题资助项目(2012ZX10001-006)
辽宁省教育厅优秀人才项目(LR2012027)
辽宁省创新团队辽教发[2009]54号(2009T101)
关键词
HIV
NKT样细胞
基线功能
Human immunoddficiency virus
NKT like cells
Baseline function
