摘要
YKL-40蛋白在肿瘤患者癌组织及外周血中高表达，参与了肿瘤细胞增殖、浸润、转移及其相关间质重塑的过程。YKL-40蛋白表达水平的增高与患者生存期缩短、治疗反应差等密切相关。因此，YKL-40蛋白可作为肿瘤诊断、病情评估及预后判断的生物标志物，并可能成为未来肿瘤治疗的新靶点。
Tissue expression and blood level of YKL-40 protein are elevated in patients with tumor. The protein may have a role in cancer cell proliferation, infiltration, metastasis and remodelling of tumor stroma. Elevated YKL-40 levels are highly associated with short survival and poor response to treatment for patients. Thus, YKL-40 may serve as a biomarker in diagnosis of disease, evaluation of severity and assessment of prognosis. It＇ s more likely to be a new target for anti-tumor treatment.
出处
《肿瘤研究与临床》
CAS
2012年第10期711-712,共2页
Cancer Research and Clinic
