摘要
选择无乳房炎临床症状且乳汁检测体细胞数大于50万/mL,CAM检测阳性的奶牛60头,依据年龄、胎次相同,泌乳日相似(产犊日期在5d以内),产奶量和泌乳期相近的原则进行配对分组。治疗组用消炎泌乳冲剂300-400g头/d,对照组不用药。结果表明:消炎泌乳冲剂可以使乳房炎奶牛血清中的IL-8、TNF-α的含量显著降低,用药后14d,IL-8的含量与试验前和对照组比,分别降低0.194ng/L和0.198ng/L,差异显著(P<0.05),用药21d分别降低0.263ng/L和0.253ng/L,用药30d分别降低0.268ng/L和0.239ng/L,差异极显著(P<0.01);TNF-α含量在用药14d、21d和30d与试验前相比,分别降低0.33ng/L、0.459ng/L和0.646ng/L,差异极显著(P<0.01),和对照组比分别降低0.372ng/L、0.504ng/L和0.678ng/L,差异极显著(P<0.01)。乳汁中的体细胞数在用药后14d极显著下降(P<0.01),21d时下降到50万/mL以下,到120d时一直维持在正常水平内。治疗组奶牛在试验期间每头牛的日产奶量比对照组提高10.98%(P<0.05),停药后3个月对照组日产奶量比治疗组降低了39.97%(P<0.01)。受试奶牛乳脂率和乳蛋白没有显著性变化。
Sixty CAM positive dairy cattle with somatic cells greater than 500 000/mL and with no mastitis clinical signs,which were of the same age,the same parity,similar lactation day（5 d within calving date）,similar previous fetal milk yield and similar lactation period,were selected and divided into groups.The experimental group was treated using ＂Lactation Anti-inflammatory Granule＂ with the dose of 300-400 g/head/d and the experiment group underwent no treatment.The test results showed that the ＂Lactation Anti-inflammatory Granule＂could significantly lower the serum content of IL-8 and TNF-α.Compared with the control group,the content of IL-8 decreased significantly to 0.194 ng/L and 0.198 ng/L（P0.05）14 days after administration of the ＂Lactation Anti-inflammatory Granule＂,and the content of IL-8 decreased very significantly（P0.01）to 0.263 ng/ L and 0.253 ng/L 21 d,after 30 d reduced to 0.268 ng/L and 0.239 ng/L.Compared with the control group,medication 14 d,21 d and 30 d compared with that before the test,the TNF-α levels reduced by 0.33 ng/L.459 ng/L and 0.646 ng/L,respectively,the difference was extremely significant（P0.01）,and that of the control group reduced by 0.372 ng/L and 0.504 ng/L and 0.678 ng/L,the difference was significant（P0.01）.21 days after administration,somatic cell content in milk dropped to less than 500 000/mL and maintained at normal levels at 120 days after administration.In the treatment group,milk yield increased by 10.98%（P0.05）compared with the control group.Three months after stopping administration,the milk yield in control group decreased by 39.97%（P0.01） than that of the treatment group.Compared with the control group,milk fat percentage and milk protein percentage did not change significantly.
出处
《家畜生态学报》
北大核心
2012年第5期63-67,共5页
Journal of Domestic Animal Ecology
基金
江苏省教育厅高校科研成果产业推进工程基金资助项目(JH08-13)
