摘要
目的研究健脑益智胶囊对颅脑损伤后大鼠血浆神经肽Y(NPY)含量的影响。方法将SD大鼠按照随机原则分成A组(假手术组)、B组(模型对照组)、C组(吡拉西坦治疗组)、D组(健脑益智胶囊治疗组);每组再按照标本采集时间随机分为4个亚组(即A1、A2、A3、A4;B1、B2、B3、B4;C1、C2、C3、C4;D1、D2、D3、D4),每组10只。采用自由落体方法造模后,C组给予吡拉西坦治疗,D组给予健脑益智胶囊治疗,治疗后第3天、5天、7天、10天观察大鼠一般状况(精神状态、进食量、行为活动度)和血浆NPY的含量变化并进行分析。结果治疗第3天B组大鼠血浆NPY含量明显高于其他各组(P均<0.05);治疗第5,7天,D组大鼠血浆NPY含量明显低于B组和C组(P均<0.05);治疗第7天,D组大鼠的精神状态和进食量明显优于B组和C组。结论健脑益智胶囊能抑制颅脑损伤后大鼠血浆NPY含量快速增高,减轻脑血管的收缩,从而改善脑组织的血供。
Objective It is to study the effect Jiannao Yizhi capsules on blood neuropeptide Y in model rats with traumatic brain injury（TBI）. Methods 160 SD rats were selected and randomly divide them into A group（ sham operation group） , B group（model control group）, C group（piracetam group） and D group （Jiannao Yizhi capsule group）, with 40 rats in each group which were divided randomly and equally into 4 subgroups （ A1, A1 , A2, A3, A4 ; B1, B2, B3, B4 ; C1 , C2, C3, C4 ; D1, D2, D3 ,D4）. After the models were established by freely falling,the rats of C group were treated with Piracetam tablets and D group with Jiannao Yizhi capsules. The general condition including mental state, food intake and activity status were observed and the Neuropeptide Y in blood at 3rd, 5th, 7th, 10th after model establishment were determined. Results The blood NPY of B group was higher than those in the other groups（P 〈 0.05） after 3 days＇treatment. After 5 and 7 das＇treatment, the content of blood NPY in group D was lower than that in group B and group C. The rats mental state and food intake of group D were better than that of group B and group after 7 days＇treatment（ P 〈 0.05 ）. Conclusion JiannaoYizhi capsules can inhibit the rapid increase of blood NPY after TBI in rats, then can lighten cerebral vasoconstriction and improve blood supply to brain tissue.
出处
《现代中西医结合杂志》
CAS
2012年第31期3437-3439,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
陕西省中医药管理局自然科学基金资助项目(2009jc21)
陕西省教育厅自然科学专项(2010JK481)
关键词
健脑益智胶囊
颅脑损伤
神经肽Y
JiannaoYizhi capsules
traumatic brain injury
neuropeptide Y
