摘要
探讨卡马西平对尿毒症性周围神经病变的治疗作用。选择45例确诊尿毒症性周围神经病变的维持性血液透析尿毒症患者,随机分为治疗组(n=23)和对照组(n=22),分别给予卡马西平(100mg,每日3次)和安慰剂治疗8周;两组患者均每周行3次常规血液透析治疗。治疗前、治疗4周、治疗8周时分别观察两组患者周围神经病变的临床症状及正中神经、胫神经、腓总神经的感觉神经传导速度(SCV).治疗8周后,对照组患者周围神经病变的临床症状及感觉神经传导速度无明显改善。而治疗组患者周围神经病变的临床症状及感觉神经传导速度较治疗前有明显改善,其程度显著优于对照组(P<0.05).卡马西平能有效地改善尿毒症性周围神经病变。
Objective To evaluate the effect of carbamazepine in treatment of uremic peripheral nervous lesion.Methods Forty-five patients with uremic peripheral nervous lesion were selected and randomly divided into therapy group（n=23） and control group（n=22）,receive respectively carbamazepine（100mg three times a day） and placebo treatment for eight weeks.All patients received regular hemodialysis thrice a week.The clinical symptoms and the sensory conduction velocity（SCV） of median nerve,tibial nerve and lateral popliteal nerve were measured in each group before,four weeks and eight weeks cost treatment respectively.Results After eight weeks treatment,the clinical symptoms,the nerve reflex and the SCV showed no obviously difference in control group,but significantly improvement in therapy group（P0.05）.Conclusion Carbamazepine are effective for patients with uremic peripheral nervous lesion.
出处
《湖北师范学院学报（自然科学版）》
2012年第3期30-32,49,共4页
Journal of Hubei Normal University(Natural Science)
关键词
卡马西平
尿毒症
周围神经病变
感觉神经传导速度
carbamazepine
uremia
uremic peripheral nervous lesion
sensory conduction velocity
