摘要
目的:探讨成人哮喘与ORMDL3基因多态性的关系。方法:选取2011年6月-2012年6月在本院就诊的哮喘病患者152例作为研究对象,纳入的研究对象必须符合家族三代以上祖居在长江以南。根据患者哮喘首次发作的年龄将研究对象分为早发组和晚发组,对照组为同期在本院进行健康体检的成人。哮喘组和对照组均通过PCR技术进行ORMDL3基因多态性分析。结果:哮喘组携带TT型基因的频率和T等位基因的频率明显高于对照组(P<0.05)。早发组与晚发组携带TT型基因和T等位基因的频率比较差异无统计学意义。结论:成人哮喘与ORMDL3基因多态性有一定的相关性,ORMDL3基因TT型纯合子可能是南方成人哮喘发生的高危基因。
Objective：To explore the relationship between ORMDL3 gene polymorphism and asthma in adult.Method：To select 152 asthma patients who lived in South China as study subjects and 140 healthy persons as controls.Furthermore,according the age of the first asthma attack of the study subjects we subdivided them into early attack group and late attack group,which were respectively compared with controls.All the cases were examined by gene polymorphism with PCR.Result：The cases with asthma carried higher frequency TT type ORMDL3 gene and T allele than healthy persons.While,healthy persons had higher frequency TC type ORMDL3 gene than the cases with asthma.Conclusion：The cases with TT type ORMDL3 gene have higher possibility of having asthma.
出处
《中国医学创新》
CAS
2012年第30期1-3,共3页
Medical Innovation of China
基金
东莞市科技计划项目(编号:201110515000130)
