摘要
目的:探讨糖尿病肾病与血清胱抑素C的相关性。方法:选取2011年3月至2012年2月在河南省人民医院内分泌科住院治疗的糖尿病患者515例为研究对象,根据蛋白尿情况分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组,比较3组患者的血清胱抑素C(CysC)、尿微量白蛋白(mAlb)、血清肌酐(Scr)、内生肌酐清除率(CG-Ccr)等临床指标。结果:从正常白蛋白尿期至微量白蛋白尿期再到大量白蛋白尿期,CysC、mAlb、Scr均逐渐升高(P<0.05),但CysC、mAlb比Scr升高较早;CG-Ccr则逐渐降低(P<0.05)。采用ACR为参照,取ACR30mg/g、ACR300mg/g为切点,作血清胱抑素C的ROC曲线并求其曲线下面积,分别为0.734(P<0.01)、0.781(P<0.01),进一步说明其较好的诊断效能。结论:CysC比Scr能更敏感地评估糖尿病肾病早期肾小球滤过率的改变。
Objective To explore the correlation between diabetic nephropathy and cystatin C.Methods 515 diabetes hospitalized in Henan Province People’s Hospital on March 2011 to February 2012,were divided into normal albuminuria group,microalbuminuria group and macroalbuminuria group,and the cystatin C（Cys C）、microalbuminuria（mAlb）、serum creatinine（Scr）,endogenous creatinine clearance rate（CG-Ccr） and other clinical parameters were compared.Results From normal albuminuria period to microalbuminuria period to macroalbuminuria period,Cys C,mAlb and Scr were increasing gradually（P 〈 0.05）,but Cys C and mAlb increased earlier than Scr;CG-Ccr decreased gradually（P 〈 0.05）.In discriminating ACR,while with a cut-off value of 30 mg/g and 300 mg/g,the area under the curve was 0.734 and 0.781 for serum cystatinC respectively（P 〈 0.01）,revealing a good diagnostic efficiency.Conclusion Cys C can evaluate glomerular filtration rate of early diabetic nephropathy more sensitively than Scr.
出处
《实用医学杂志》
CAS
北大核心
2012年第20期3455-3457,共3页
The Journal of Practical Medicine
关键词
胱抑素C
血清肌酐
糖尿病肾病
Cystatin C
Serum creatinine
Diabetic nephropathy
