摘要
目的:评价冻干重组人脑利钠肽(rhBNP)治疗心肌梗死合并急性心力衰竭的安全性和有效性。方法:48例急性心肌梗死后心力衰竭患者被随机分为两组,常规治疗组(24例,给予常规治疗),rhBNP组(24例,在常规治疗的基础上加用rhBNP),观察治疗前后两组患者的各项临床指标,评价临床疗效。结果:治疗后与常规治疗组比较,rhBNP组总有效率明显提高(66.7%比91.7%),每搏量[(72.35±9.85)ml比(84.97±9.31)ml]、每分输出量[(4.49±1.52)L/min比(6.78±1.66)L/min]、左室射血分数[(44.8±8.82)%比(56.8±10.2)%]均有明显改善(P<0.05)。结论:rhBNP能迅速改善心肌梗死合并心力衰竭患者的心功能,疗效确切,值得临床推广应用。
Objective： To evaluate safety and efficacy of Lyophilized recombinant human brain natriuretic peptide （rhBNP） in treatment of myocardial infraction complicated acute heart failure. Methods： A total of 48 patients with heart failure after acute myocardial infarction were randomly divided into routine treatment group （n = 24, received routine treatment） and rhBNP group （n = 24, received rhBNP based on routine treatment）. Clinical indexes were observed and clinical therapeutic effects were evaluated in two groups before and after treatment. Results： Com- pared with routine treatment group after treatment, there were significant increase in total effective rate （66. 7% vs. 91.7%）, stroke volume [（72.35±9.85） ml vs. （84.97 ±9.31） ml], cardiac output [- （4.49± 1.52） L/min vs. （6.78± 1.66） L/mini and left ventricular ejection fraction [ （44.8± 8.82） % vs. （56.8 ± 10.2） %] in rhBNP group, P〈0.05 all. Conclusion： The rhBNP can quickly improve heart function in patients with myocardial infarction complicated heart failure, so should be spread
出处
《心血管康复医学杂志》
CAS
2012年第5期537-539,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗塞
心力衰竭
充血性
利钠肽
脑
Myocardial infraction
Heart failure, congestive
Natriuretic peptide, barain
