摘要
目的:探讨男性乳腺癌患者的临床病理特征以及治疗和生存情况,并进行预后相关因素的分析。方法:回顾性分析1961年1月—2011年12月共125例男性乳腺癌患者的病历资料和随访资料。采用log-rank检验和COX回归模型分析与男性乳腺癌患者预后相关的因素。结果:125例男性乳腺癌患者的5年总生存率为60.5%,5年无病生存率为54.8%。单因素分析结果显示,是否有恶性肿瘤家族史(P=0.041)、肿瘤大小(P=0.005)、临床TNM分期(P=0.005)、腋窝淋巴结是否转移(P=0.013)和是否行乳腺癌根治术(P=0.016)是与男性乳腺癌患者总生存率相关的预后因素,而是否有恶性肿瘤家族史(P=0.015)、肿瘤大小(P=0.000)、临床TNM分期(P=0.002)和腋窝淋巴结是否转移(P=0.010)是与男性乳腺癌患者无病生存率相关的预后因素。COX回归模型分析结果显示,肿瘤大小(P=0.045)、腋窝淋巴结是否转移(P=0.026)和是否行乳腺癌根治术(P=0.000)是与总生存率相关的独立预后因素,而肿瘤大小(P=0.010)和是否行乳腺癌根治术(P=0.001)是与无病生存率相关的独立预后因素。结论:肿瘤大小、腋窝淋巴结是否转移和是否行乳腺癌根治术是影响男性乳腺癌患者预后的独立危险因素,早期诊断以及以乳腺癌根治术为主的综合治疗措施是提高男性乳腺癌患者生存率的关键。
Objective： This study is aimed to evaluate the clinicopathological features, treatment protocols and survival of male patients with breast cancer, and to explore the prognostic factors for male breast cancer （MBC）. Methods： Medical records and follow-up information of 125 patients with histopathologically confirmed MBC between January 1961 and December 2011 were retrospectively reviewed. The log-rank test and COX regression model were used to evaluate the prognostic factors for MBC. Results： The 5-year overall survival rate was 60.5% and the 5-year disease-free survival rate was 54.8%. Univariable analysis showed that the family history of cancer （P = 0.041）, tumor size （P = 0.005）, clinical TNM staging （P = 0.005）, axillary lymph node status （P = 0.013） and surgical procedure （radical mastectomy vs modified radical mastectomy） （P = 0.016） significantly influenced the overall survival; the family history of cancer （P = 0.015）, tumor size （P = 0.000）, clinical TNM staging （P = 0.002） and axillary lymph node status （P = 0.010） significantly influenced the disease-free survival. Multivariable COX regression analysis showed that the tumor size （P = 0.045）, axillary lymph node status （P = 0.026） and surgical procedure （radical mastectomy vs modified radical mastectomy） （P = 0.000） were independent prognostic factors of overall survival for MBC; the tumor size （P = 0.010） and surgical procedure （radical mastectomy vs modified radical mastectomy） （P = 0.001） were independent prognostic factors of disease-free survival for MBC. Conclusion： The tumor size, axillary lymph node status and surgical procedure are independent prognostic factors for MBC. Early diagnosis and radical mastectomy-based comprehensive treatment are essential to improve the survival of patients with MBC.
出处
《肿瘤》
CAS
CSCD
北大核心
2012年第10期805-810,共6页
Tumor
关键词
乳腺肿瘤
男性
预后
无病生存
总生存
Breast neoplasms, male； Prognosis； Disease-free survival； Overall survival
