摘要
目的评价β-内酰胺类抗生素联合大环内酯类与单用氟喹诺酮类治疗社区获得性肺炎的疗效。方法收集符合纳入及排除标准的2010年1月1日至2011年6月30日期间就诊于浙江大学医学院附属第一医院的社区获得性肺炎临床资料并进行分析。结果有89例病例纳入本次研究,其中56例接受β-内酰胺类抗生素加大环内酯类,33例单用氟喹诺酮类治疗。两组患者在年龄,性别组成,合并症,入院前抗生素治疗,影响体温药物的应用,体征及部分实验室检查等方面差异均无统计学意义(P>0.05)。在临床疗效评价上,两组在入院后退热时间、住院时长及CRP下降80%时间差异均无统计学意义(P>0.05),根据PSI进行亚组分析差异亦无统计学意义。结论β-内酰胺类抗生素联合大环内酯类与单用氟喹诺酮类在治疗轻中度社区获得性肺炎时,二者疗效相当。
Objective To compare curative effects between β-lactam plus macrolides and fluoroquinolone alone in treatment of community acquired pneumonia.Methods Retrospective Study was performed with patients diagnosed as CAP from Jaunuary 2010 to June 2011.Results Total of 89 CAP patients were included,among which 56 patients were prescribed fluoroquinolone and 33 patients were β-lactam plus macrolide.There were no significant differences in ages,genders,complications,previous antibiotics usage,antipyetics,physical signs and results of laboratory examination between these two groups（P〈0.05）.There were no statistical differences in curative effects such as time of fever continuing,time of hospitalization,time of CRP 80% decrease between two groups（P〈0.05）.There was also no significant difference by PSI subgroup analysis.Conclusion The curative effects of β-lactam plus macrolides and fluoroquinolone alone were similar in treatment of community acquired pneumonia.
出处
《中国微生态学杂志》
CAS
CSCD
2012年第10期904-906,共3页
Chinese Journal of Microecology
基金
国家自然科学基金(81000757)
教育部博士点基金(20100101120119)
